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By Jamie McGeever (Reuters) - A look at the day ahead in Asian markets. A sudden burst of political chaos in South Korea has put investors in Asia on the defensive, pointing to a cautious market open across the continent on Wednesday despite Wall Street's resilience the previous day. South Korea's President Yoon Suk Yeol declared martial law on Tuesday to thwart "anti-state forces" among his opponents, creating the most serious challenge to the country's democracy since the 1980s, only to lift it hours later after lawmakers rejected the move and protesters gathered outside parliament. The initial declaration had an immediate impact on the won, slamming it to a 2-year low against the dollar. At one point, it was down 2% and set for its biggest one-day loss since Nov. 9, 2016, the day after the 2016 U.S. election that swept Donald Trump to power and started the clock ticking on a looming trade war with China. This cemented the won's unwanted status as the worst-performing major Asian currency against the dollar this year, bringing its year-to-date losses to nearly 10%. The benchmark Kospi is also one of the worst-performing equity indexes in Asia this year, down nearly 6% year-to-date at Tuesday's close. Yoon's about face, however, appears to have restored a sense of calm. The won is still weaker but reclaimed more than half its losses from earlier on Tuesday. Kospi futures traded on the Eurex exchange are pointing to a fall at the stock market open in Seoul of only around 0.3%. Elsewhere in Asia, India's rupee is at a record low, while China's yuan is at a 13-month low and seemingly poised for a break below 7.30 per dollar, as traders speculate Beijing is allowing it to slide as trade tensions with Washington heat up. China on Tuesday announced a ban on exports of 'dual-use items' related to key minerals gallium, germanium, antimony and superhard materials to the United States. This came 24 hours after the U.S. launched a third crackdown in three years on China's semiconductor industry, curbing exports to 140 firms. If volatility in key assets across Asia is spiking, U.S. market volatility right now is pretty subdued. The VIX 'fear index' on Tuesday hit its lowest since July, and the MOVE index of implied volatility in U.S. Treasuries has tumbled since the U.S. presidential election to a two-month low. The Asian calendar on Wednesday sees the release of Australian GDP, Thai inflation, and a raft of purchasing managers index reports for November, including China's Caixin services PMI. Australia's economy is expected to have expanded at a 0.4% pace in the July-September period, twice the rate of the previous quarter, and at a 1.1% year-on-year pace, a marginal uptick from the 1.0% annual growth registered in Q2. Here are key developments that could provide more direction to markets on Wednesday: - Reaction to South Korea political instability - Australia GDP (Q3) - PMIs, including China's 'unofficial' services (November) (Reporting by Jamie McGeever; Editing by Bill Berkrot)

Investigators probing South Korea's Yoon Suk Yeol over his short-lived declaration of martial law said Monday they sought an arrest warrant for the suspended president after he failed to report for questioning. Yoon briefly suspended civilian rule this month, plunging South Korea into its worst political crisis in decades. He was stripped of his presidential duties by parliament over the action, but a constitutional court ruling is pending on whether to confirm the impeachment. The conservative leader also faces criminal charges of insurrection, which could result in life imprisonment or even the death penalty. A former prosecutor himself, Yoon had been summoned three times by investigators for questioning, but refused to present himself each time -- including by yesterday's deadline. "The Joint Investigation Headquarters filed an arrest warrant for President Yoon Suk Yeol with the Seoul Western District Court", said the probe team in a statement. The application by investigators marks the first attempt in the country's history to forcibly detain a president before the impeachment procedure is complete. Yoon is being investigated by prosecutors as well as a joint team comprising police, defence ministry, and anti-corruption officials. A 10-page prosecutors' report seen by AFP stated that Yoon authorised the military to fire weapons if needed to enter parliament during his failed martial law bid. Yoon's lawyer Yoon Kab-keun had dismissed the prosecutors' report, telling AFP it was "a one-sided account that neither corresponds to objective circumstances nor common sense". Yoon declared martial law in an unannounced televised address on December 3, saying it was aimed at eliminating "anti-state elements". Lawmakers rushed to parliament within minutes of the declaration to vote it down. At the same time, heavily armed troops stormed the building, scaling fences, smashing windows and landing by helicopter. According to the prosecution indictment report, Yoon told the chief of the capital defence command, Lee Jin-woo, that military forces could shoot if necessary to enter the National Assembly. "Have you still not got in? What are you doing? Break down the door and drag them out, even if it means shooting," Yoon told Lee, according to the report. Yoon also allegedly told the head of the Defense Counterintelligence Command, General Kwak Jong-keun, to "quickly get inside" the National Assembly since the quorum for lifting the martial law declaration had not been met. "So quickly get inside the National Assembly and bring out the people inside the chamber, and break down the doors with an axe if necessary and drag everyone out," the report quotes Yoon as saying at the time. The report also said there was evidence that Yoon had been discussing declaring martial law with senior military officials as early as March. As investigations began against Yoon, attempts by prosecutors to search his offices were blocked by the presidential security team. South Korea's political turmoil deepened late last week when Yoon's replacement, Han Duck-soo, was also impeached by parliament for failing to sign through bills for investigations into Yoon. Finance Minister Choi Sang-mok has taken over as the new acting president, and found himself thrust immediately into a disaster with the Jeju Air plane crash that claimed 179 lives.

Son in police net for stabbing mother to death in BayelsaDillon Gabriel was faced with a quandary when he arrived at Oregon this year. Gabriel had worn No. 8 at Oklahoma before transferring for his sixth season of eligibility. But in Eugene, that number had special significance because it had been worn by Heisman Trophy winner Marcus Mariota. There were many similarities between the two: They were both dual-threat quarterbacks who had piled up accolades along with yards and touchdowns. Both hailed from Hawaii and were shaped by the island spirit. Mariota chose the No. 8 initially because of the number of Hawaiian islands. His helmet's facemask was formed in an 808, Hawaii's area code. So Gabriel took a leap of faith and texted Mariota to ask his permission. Mariota, now with the NFL's Washington Commanders, said yes. "You know, when you’re growing up and you have that kind of direct example, a guy from Hawaii, playing at a high level, at the DI level, and then you see him go to the NFL, it’s like you can see it, you can believe it,” Gabriel said. Gabriel has led the top-ranked Ducks (12-0, 9-0 Big Ten) through an undefeated season and on to the Big Ten title game on Saturday against No. 4 Penn State (11-1, 8-1) in Indianapolis. Gabriel — who played his first three years at Central Florida before joining the Sooners — became the all-time NCAA leader for total career touchdowns along the way and now has 183, including 149 via pass, 33 via rush and one reception. He's tied with former Oregon quarterback Bo Nix — now with the Denver Broncos — with an FBS-record 61 career starts. Ever humble, Gabriel is thoughtful about the arc of his career. "I think we’re in an interesting time that’s all about results. And so many people talk about the process but aren’t patient enough. I think if you look at my body of work, I’m a guy who’s eager and wants to get better but has had that time to develop and work in that way. I think you see it over time," Gabriel said. As a Duck, Gabriel has thrown for 3,277 yards and 24 TDs in 12 games. He's rushed for seven more scores. Mariota spent his three-year college career at Oregon, throwing for 104 touchdowns and running for 29 more. He was the Ducks' quarterback in the 2014 season, the last time Oregon advanced to the national championship game. "I mean, everybody would love to run out there with the experience that we have at quarterback right now,” Oregon coach Dan Lanning said. “And I think that experience shows up consistently every Saturday for us. More than anything, just the ability for Dillon to be calm within the chaos that exists in a football game, and being a great decision-maker and understanding the scheme.” The only other time Oregon finished the regular season 12-0 was in 2010, when the Ducks played for the BCS national championship. Among the team's victories this season was a 32-31 win at home over Ohio State and a 38-17 victory over Michigan at the Big House. The Ducks capped the season with a 49-21 victory over rival Washington , finishing 9-0 in their first Big Ten year. Gabriel threw for a pair of touchdowns and ran for another in that game. The Nittany Lions advanced to the conference title game with a 44-7 victory over Maryland on Saturday. They were helped by Ohio State’s 13-10 loss to Michigan in Columbus. Oregon has played the Nittany Lions just one other time, in the 1995 Rose Bowl. Penn State, led by Joe Paterno, won that one, 38-20. The winner in Indianapolis this weekend can secure a first-round bye in the expanded 12-team playoffs. Both teams are assured of a playoff berth even with a loss. On Tuesday, Gabriel added another honor when he was named Big Ten offensive player of the year. "He’s earned the trust and the admiration of all his teammates and the coaches around him," Lanning said. "This guy prepares extremely hard. He is the calmest dude you’ve ever been around on the field, which is impressive, but I’m really proud of him and what he’s been able to do for this team.” Get poll alerts and updates on the AP Top 25 all the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football

Dillon Gabriel's run at Oregon harkens back to the days of another Hawaii-born QB, Marcus MariotaAP Business SummaryBrief at 4:21 p.m. EST

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Kenny Pickett is making preparations to start at quarterback for the Philadelphia Eagles in Week 17. Jalen Hurts suffered a concussion in the Eagles’ loss to the Washington Commanders last weekend, which led Pickett to play most of the game for Philly. If Hurts is unable to clear concussion protocol ahead of Sunday’s game, then Pickett would be in line for the start. Pickett suffered an injury to his ribs in Week 16 but said Thursday he would be ready for action, though he would make some adjustments with his padding. “Tested out some different things padding-wise. I’ll just make sure I feel good with it for Sunday,” Pickett told reporters. “I’ll be ready to go for Sunday.” Pickett said that after having some rest and rehab time, he will be better. Pickett went 14/24 for 143 yards with a touchdown and an interception in the Eagles’ 36-33 loss to the Commanders. He rushed 3 times for 13 yards. That was the first significant action of the season for the third-year QB. Pickett is in his first season with the Eagles. The former Pittsburgh Steelers first-round pick was limited in practice on Wednesday but was a full participant on Thursday, which is a good sign of his progress ahead of Sunday’s game against the 7-8 Dallas Cowboys. The Eagles are 12-3 and can clinch the NFC East with a win against Dallas. This article first appeared on Larry Brown Sports and was syndicated with permission.Federal GST holiday 'biggest bonus you’ll ever see,' says Niagara restaurateur

Michigan fired offensive coordinator and quarterbacks coach Kirk Campbell after one season under coach Sherrone Moore, the school announced Tuesday. Tight ends coach Steve Casula will serve as the interim coordinator while the program searches for a new coordinator. Campbell was hired as quarterbacks coach under coach Jim Harbaugh and helped the Wolverines win the 2023 national championship. When Harbaugh left, Moore was promoted to coach and Campbell to offensive coordinator and play caller. However, the Michigan offense fell apart in Campbell's lone season, dropping from No. 69 to 128. The Wolverines were one of only five power conference programs to average fewer than 300 yards per game. One year after going 15-0 with a national championship, Michigan finished 7-5. "After a thorough assessment of our offense, I made the decision to relieve Kirk Campbell of his duties and move in a different direction," Moore said in a statement released by the school. "This was a decision that I felt was in the best interest of our football program. I want to thank Kirk for his hard work and dedication to the university, Michigan Football and our student-athletes. I wish him well in his future coaching endeavors." Campbell's quarterback room was especially egregious during the letdown season. Michigan ranked No. 130 nationally in passing offense, leading only the three service academies and Iowa at 133.6 yards per game and led only New Mexico State in yards per attempt (5.5). Three different quarterbacks played major snaps: Davis Warren , Jack Tuttle and Alex Orji . Michigan's next offensive coordinator hire will be critical as the program prepares to welcome No. 1 overall recruit Bryce Underwood in the Class of 2025. The Wolverines boast the No. 7 class in the country and four of their top five recruits are on offense.Dillon Gabriel's run at Oregon harkens back to the days of another Hawaii-born QB, Marcus Mariota

MITCHELL — Along with showcasing top teams and talents from South Dakota each winter, the Hoop City Classic has a reputation for bringing in programs from across the country to compete. This year’s Hoop City Classic slate features six out-of-state teams that are set to compete in 12 total games across the four-day event. These visitors take center stage on Friday night, as they're paired up against each other in three games to tip off the weekend's action. ADVERTISEMENT Here’s a closer look at the programs making the trip to Mitchell this weekend: Henderson, Nevada Record: 3-3 HCC opponents: Totino-Grace (Minn.), 6:30 p.m. Dec. 27; Sioux Falls Christian, 9 p.m. Dec. 28. Player to watch: Lantz Stephenson, sr., 6-6, wing. Ranked as Nevada’s No. 3 prospect in the 2025 class, Stephenson is a three-star small forward with college offers from UNLV, Northern Arizona and Manhattan. Last season, Stephenson provided 15.4 points and 6.4 rebounds per game. What to know: This year marks the Coronado program’s third appearance in the Hoop City Classic, having also made the nearly 1,700-mile trek in 2012 and 2018. The Cougars are 2-3 all-time at the event. Coronado was ranked as the No. 12 overall team in Nevada by MaxPreps on Dec. 26. Germantown, Tennessee Record: 10-0 HCC opponents: Orono (Minn.), 8 p.m. Dec. 27; Totino-Grace (Minn.), noon Dec. 28; St. Thomas More, 6 p.m. Dec. 28; Hamlin, 9 p.m. Dec. 30. Player to watch: Justin Frison, so., 6-2, guard. A product of the Hoop City Basketball Club, PrepHoops Tennessee ranks Frison as the state’s top prospect in the class of 2027. Playing for HCBC in the summer of 2024, Frison garnered offers from Tennessee State and Alabama State. What to know: Houston was ranked as the No. 3 overall program in Tennessee by MaxPreps on Dec. 26. Though not part of last season’s field, the Mustangs are making their fourth trip to Mitchell, all since 2019. They are 5-5 all-time at the event. Orlando, Florida Record: 3-7 HCC opponents: St. George’s (Tenn.), 5 p.m. Dec. 27; Harrisburg, 1:30 p.m. Dec. 28; Mitchell, 7:30 p.m. Dec. 30. Player to watch: Josh Theus, jr., 6-2, guard. Taking over a leading role for OCP this season, Theus has shined with a hand in everything, posting 15.5 points, 7.8 rebounds, 4.6 assists and 1.6 steals per game. What to know: One of two Hoop City Classic debutants in this year’s out-of-state contingent, the Warriors are coming off a state runner-up finish in Florida’s Class 2A last season. OCP’s 25-5 record from last season extended a streak of five-straight 25-win campaigns for the perennial power, which has five state titles since 2017. Long Lake, Minnesota Record: 4-1 HCC opponents: Houston (Tenn.), 8 p.m. Dec. 27; Mitchell, 7:30 p.m. Dec. 28. Player to watch: Brady Wooley, sr., 6-9, forward. Minnesota’s No. 4 overall recruit for the class of 2025 is a three-star with offers from the University of North Dakota and Yale, per 247 Sports. Last season, he averaged 14.2 points, 11.1 rebounds and 4.4 assists per game. ADVERTISEMENT What to know: Ranked No. 2 in Minnesota’s Class 3A, the second-largest class in the state, Orono enters the Hoop City Classic having already faced a challenging gauntlet. The Spartans own wins over Fargo Davies, a No. 1-ranked team from North Dakota, and Wayzata, which was No. 1 in Minnesota’s Class 4A at the time, while their lone loss to date came against new Class 4A No. 1 Cretin-Derham Hall. Orono’s only prior appearance in the Hoop City Classic came in 2022, when it went 1-1. Collierville, Tennessee Record: 6-1 HCC opponents: Orlando Christian Prep (Fla.), 5 p.m. Dec. 27; Lower Brule, 9 a.m. Dec. 28; Brandon Valley, noon Dec. 30. Player to watch: Carson Crump, fr., 5-10, guard. Though just a freshman, Crump is a budding star, averaging 21 points, 3.1 assists and 2.6 steals per game. What to know: The other Hoop City Classic debutant among this year’s out-of-state programs, St. George’s joins a long line of programs to participate in the Hoop City Classic from the Memphis metro area, where the Hoop City Basketball Club is headquartered. Fridley, Minnesota Record: 4-3 HCC opponents: Coronado (Nev.), 6:30 p.m. Dec. 27; Houston (Tenn.), noon Dec. 28. Player to watch: Tyler Wagner, sr., 6-5, wing. Wagner is a three-star recruit and holds a handful of college offers ranging from the University of North Dakota to High Point University in North Carolina, per 247Sports. He scored 17 points in Totino-Grace’s state title win last season and earned all-tournament honors. What to know: The lone out-of-state holdover from last year, 2024 marks the Eagles’ fourth-straight appearance in the Hoop City Classic, having previously gone 3-2. The Eagles are three-time defending state champions and currently ranked No. 4 in Minnesota’s Class 3A, the second-largest class in the state.

South Korean authorities seek warrant to detain impeached President Yoon in martial law probe

UTRECHT, The Netherlands and CAMBRIDGE, Mass., Dec. 16, 2024 (GLOBE NEWSWIRE) -- Merus N.V . (Nasdaq: MRUS), a clinical-stage oncology company developing innovative, full-length multispecific antibodies (Biclonics ® and Triclonics ® ) for cancer, today announced that the first patient has been dosed in the Company's phase 2 trial evaluating petosemtamab monotherapy in heavily pretreated (3L+) metastatic colorectal cancer (mCRC). Petosemtamab is a Biclonics ® targeting EGFR and LGR5. The phase 2, open-label trial will evaluate the safety and antitumor activity of petosemtamab monotherapy in 3L+ mCRC, post anti-EGFR therapy. To be eligible for enrollment, patients must lack certain mutations as detected in plasma by ctDNA NGS, including KRAS, NRAS. "We discovered petosemtamab from an unbiased screen of over 500 bispecific antibodies tested for the ability to inhibit cancer-derived, as compared to matched normal tissue derived, organoids. In preclinical CRC models, petosemtamab consistently demonstrates superior activity compared to cetuximab, a mainstay therapy in mCRC,” said John de Kruif Ph.D., Chief Technology Officer at Merus. "I am hopeful our unique platform technologies will translate into improved therapies for patients with heavily pretreated mCRC.” About Petosemtamab Petosemtamab, or MCLA-158, is a Biclonics ® low-fucose human full-length IgG1 antibody targeting the epidermal growth factor receptor (EGFR) and the leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5). Petosemtamab is designed to exhibit three independent mechanisms of action including inhibition of EGFR-dependent signaling, LGR5 binding leading to EGFR internalization and degradation in cancer cells, and enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) activity. About Merus N.V. Merus is a clinical-stage oncology company developing innovative full-length human bispecific and trispecific antibody therapeutics, referred to as Multiclonics ® . Multiclonics ® are manufactured using industry standard processes and have been observed in preclinical and clinical studies to have several of the same features of conventional human monoclonal antibodies, such as long half-life and low immunogenicity. For additional information, please visit Merus' website and LinkedIn . Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation, statements regarding the evaluation of petosemtamab in patients with mCRC, the clinical study design and objectives of the phase 2 study; and the hope that our unique platform technologies will translate into improved therapies for patients with heavily pretreated mCRC. These forward-looking statements are based on management's current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: our need for additional funding, which may not be available and which may require us to restrict our operations or require us to relinquish rights to our technologies or antibody candidates; potential delays in regulatory approval, which would impact our ability to commercialize our product candidates and affect our ability to generate revenue; the lengthy and expensive process of clinical drug development, which has an uncertain outcome; the unpredictable nature of our early stage development efforts for marketable drugs; potential delays in enrollment of patients, which could affect the receipt of necessary regulatory approvals; our reliance on third parties to conduct our clinical trials and the potential for those third parties to not perform satisfactorily; impacts of the volatility in the global economy, including global instability, including the ongoing conflicts in Europe and the Middle East; we may not identify suitable Biclonics ® or bispecific antibody candidates under our collaborations or our collaborators may fail to perform adequately under our collaborations; our reliance on third parties to manufacture our product candidates, which may delay, prevent or impair our development and commercialization efforts; protection of our proprietary technology; our patents may be found invalid, unenforceable, circumvented by competitors and our patent applications may be found not to comply with the rules and regulations of patentability; we may fail to prevail in potential lawsuits for infringement of third-party intellectual property; and our registered or unregistered trademarks or trade names may be challenged, infringed, circumvented or declared generic or determined to be infringing on other marks. These and other important factors discussed under the caption "Risk Factors” in our Quarterly Report on Form 10-Q for the period ended September 30, 2024, filed with the Securities and Exchange Commission, or SEC, on October 31, 2024, and our other reports filed with the SEC, could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management's estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change, except as required under applicable law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release. Multiclonics ® , Biclonics ® and Triclonics ® are registered trademarks of Merus N.V. CONTACT: Investor and Media Inquiries: Sherri Spear Merus N.V. SVP Investor Relations and Strategic Communications 617-821-3246 [email protected] Kathleen Farren Merus N.V. Assoc. Director IR/Corp Comms 617-230-4165 [email protected]

By A Staff Reporter,Kathmandu, Dec. 11: Kathmandu Metropolitan City in coordination with the Partnership for Healthy Cities Initiative has started the installation of air quality monitoring devices in 18 locations of the Kathmandu Metropolitan City. At a programme organised at the KMC main office building, the first air quality monitoring site was inaugurated by Deputy Mayor Sunita Dangol on Monday. The Partnership for Healthy Cities Initiative is supported by Bloomberg Philanthropies, in partnership with the World Health Organisation (WHO) and the global health organisation ‘Vital Strategies’. The Partnership for Healthy Cities Initiatives (PHCI) is implemented by the National Federation of Youth NGO Nepal (NFYN) in close coordination with the KMC office. Speaking at the programme, Deputy Mayor Dangol said, “This is an important initiative launched by KMC to control pollution and demonstrate the KMC's commitment to tackling air pollution. We have a responsibility to provide clean and fresh air to every citizen, and this is the first important step by the KMC, which can provide valuable insights for policy-making level for controlling air pollution.” She said, “We have also taken initiatives to clean the city by discouraging open burning and raising awareness about its harmful effects. Similarly, we have started a vehicle-free Handigaun on Saturdays, which is part of our effort to reduce carbon emissions while offering social and cultural benefits to the local community.” Dangol shared the strong commitment of KMC to utilising data from these devices in well-informed policies and ensuring that every city resident's right to live in a healthy city is ensured. She also assured that the device would not remain only as a showcase event but also the beginning of something substantial in reducing air pollution in the city. KMC is the first local government entity to initiate air quality monitoring on its own. Through this initiative, KMC is installing 18 sensors to monitor PM 2.5 concentration on their own to support the city office in developing data-based policies and interventions at the localised level. Clarity Node-S is the device procured under the initiative which is trusted by more than 70 governments from London to Bogota to Jakarta. According to Sanjeeb Pandey, Project Lead, PHCI Project for Kathmandu, the device comes with a solar-powered system and does not require any power supply. In addition, the device has data connectivity built up in the device that can relay real-time data in the dashboard. All the devices being installed by KMC have undergone the process of custom colocation and calibration with ground stations in support of the Department of Environment. The process of calibration further ensures the data reliability and accuracy as prescribed by USEPA, he said. He also briefed the technical details of the device and also shared about making the data public through the web portal and app of KMC. He also urged all private and public entities to be a part of the 'Air Pollution Awareness Month Campaign.' Sarita Rai, Head of the Environment Management Department of KMC, said, “KMC is committed to improving the air quality in the city and is launching several programmes such as vehicle testing and severity on open waste burning.” She also announced the month of Poush (December/January) as “Air Pollution Awareness Month” in coordination with the Partnership for Healthy Cities Project. Rajaram Shrestha, National Programme Officer of the WHO Nepal office, highlighted the significance of mitigating health risks as he emphasised air pollution risk as a 'Silent Killer.' The PHCI is a prestigious global network of 74 cities committed to saving lives by preventing non-communicable diseases (NCDs) and injuries.Longstanding SFUSD volunteer nears end of era