ubet63 free 100 Machine learning reveals behaviors linked with early Alzheimer's, points to new treatments November 26, 2024 Gladstone Institutes Scientists used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develops over time. Facebook Twitter Pinterest LinkedIN Email Subtle signs of Alzheimer's disease can emerge decades before a diagnosis -- often in the form of irregular behaviors that reflect very early stages of brain dysfunction. But until now, identifying and measuring these slight behavioral changes in a scientific way hasn't been feasible, not even when studying Alzheimer's in mice. In a study published in Cell Reports, a team of scientists at Gladstone Institutes used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develops over time. "We've shown the potential of machine learning to revolutionize how we analyze behaviors indicative of early abnormalities in brain function," says Gladstone investigator Jorge Palop, PhD, senior author of the study. "We leveraged a valuable tool that opens the door to a more complete understanding of devastating brain disorders and how they begin." The scientists used a machine learning platform called VAME, short for "Variational Animal Motion Embedding," to analyze video footage of mice exploring an open arena. The open-source tool identified subtle behavioral patterns captured on camera -- changes that might not be noticed by simply looking at the mice. Tracking Disorganized Behavior VAME's deep learning platform is unlike conventional behavioral tests in mice, which often center around preconceived tasks that the animals are challenged to complete. Among the limitations of those tests, they can't capture the full range of spontaneous behavioral changes caused by disease -- particularly in early stages, explains Stephanie Miller, PhD, staff scientist at Gladstone and first author of the study. They also lack scalability and often rely on labor-intensive methods. For the Gladstone study using VAME, the team evaluated two types of mice that simulated different aspects of Alzheimer's. In both models, the machine learning tool identified a significantly increased level of "disorganized behavior" as the mice aged. For example, the mice exhibited unusual patterns of behavior and transitioned more often between different activities -- factors that might be associated with memory and attention deficits. "Similar machine learning approaches could be used one day to study spontaneous behaviors in humans, potentially providing early diagnosis of neurological diseases," Miller says, noting that smartphone-quality video is sufficient for VAME analysis. "I envision this technology will be used to assess patients in the clinic and even in their homes. It gives scientists and doctors a way to solve the very hard problem of diagnosing preclinical stages of disease." Miller began experimenting with VAME several years ago when the technology was still in its infancy. She and Palop collaborated with the team of Stefan Remy, MD, in Germany, which initially developed the platform. Together, they helped demonstrate VAME's utility for neuroscience research in a study published in Communications Biology . Evaluating a Potential Treatment Adding another dimension to their new study, the Gladstone team used VAME to learn whether a potential therapeutic intervention for Alzheimer's would prevent the disorganized behavior in mice. The scientists leveraged prior research from Gladstone investigator Katerina Akassoglou, PhD, who discovered that a blood-clotting protein called fibrin creates a cascade of toxic effects when it leaks into the brain through damaged blood vessels. By blocking fibrin's toxic effects, Akassoglou's lab has been able to prevent the neurodegeneration that leads to cognitive decline and to protect against Alzheimer's in animals. To find out if this therapeutic strategy could safeguard mice from Alzheimer's-linked behaviors, the team genetically blocked fibrin from triggering toxic inflammation in the brain. This intervention reduced the development of abnormal behaviors in the Alzheimer's mice. "It was highly encouraging to see that blocking fibrin's inflammatory activity in the brain reduced virtually all of the spontaneous behavioral changes in Alzheimer's mice, reaffirming that fibrin and the ensuing neuroinflammation are key drivers of the disease," says Akassoglou, also an author of the study. "Machine learning can offer an unbiased way to evaluate potential treatments in the lab -- and I believe it may ultimately become an invaluable clinical tool, as well." Palop and Miller are now working with other Gladstone teams who study neurological disease to help them employ the VAME technology for new behavioral studies. "My goal is to make this tool and similar approaches more accessible to biologists and clinicians in order to shorten the time it takes to develop powerful new medicines," Miller says. About the Study The study, "Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models," appears in the November 26 issue of Cell Reports . Authors include Stephanie Miller, Kevin Luxem, Kelli Lauderdale, Pranav Nambiar, Patrick Honma, Katie Ly, Shreya Bangera, Mary Bullock, Jia Shin, Nick Kaliss, Yuechen Qiu, Catherine Cai, Kevin Shen, K. Dakota Mallen, Zhaoqi Yan, Andrew Mendiola, Takashi Saito, Takaomi Saido, Alexander Pico, Reuben Thomas, Erik Roberson, Katerina Akassoglou, Pavol Bauer, Stefan Remy, and Jorge Palop. Story Source: Materials provided by Gladstone Institutes . Original written by Kelly Quigley. Note: Content may be edited for style and length. Journal References : Cite This Page :

CARSON — It was the perfect start to the perfect end of the 2024 season for the Galaxy. Within the first 15 minutes, just barely enough time after the pregame festivities, the Galaxy seized control, first with Joseph Paintsil’s opening goal, followed by Dejan Joveljic for a quick two-goal lead. From there, the Galaxy, who had been known to run up the scoreboard, dug in and eventually saw a 2-1 win, claiming the club’s sixth MLS Cup title, Saturday at Dignity Health Sports Park in front of 26,812. This was the Galaxy’s first MLS Cup appearance since 2014. After going unbeaten at home in the regular season, the Galaxy is now unbeaten (4-0) at home in MLS Cups. Last year at this time, the Galaxy was well into their offseason rebuilding project. The 2023 regular season was dismal, finishing in 13th place in the Western Conference, but before contending for the MLS Cup, the Galaxy had to win its offseason. And that’s what they did, with the acquisitions of goalkeeper John McCarthy and defender John Nelson and the signings of Designated Players Paintsil and Gabriel Pec. The moves, coupled with the re-emergence of Joveljic and fiery Riqui Puig paid dividends during the season. One question for Saturday was how the Galaxy would replace Puig, who suffered an ACL injury in last week’s conference final win against Seattle. In stepped Gaston Brugman, who hadn’t appeared in the starting lineup since Oct. 5 and had just three starting assignments since September. Brugman assisted on Paintsil’s opening goal, slotting a ball from midfield through the defense right to Paintsil in the ninth minute. Joveljic made it 2-0 in the 13th minute. The Red Bulls received a lifeline in the 28th minute on Sean Nealis’ goal after the Galaxy failed to clear a corner kick. The Red Bulls had a stretch of four consecutive corner kicks later in the half to test the Galaxy’s structure, but weren’t able to break through. Related Articles The Red Bulls, seeking their first MLS title, received a bit of bad news before the game as center back Andres Reyes was removed from the starting lineup due to an illness. This was the first MLS Cup appearance for the Red Bulls since 2008. The Red Bulls were the seventh seed in the Eastern Conference and recorded three consecutive upsets to advance, knocking second-seeded Columbus in the first round, sixth-seeded New York City FC in the conference semifinal and third-seeded Orlando City in the conference final. More to come on this story.

Sports on TV for Friday, Dec. 20Hyderabad: In cosmopolitan Hyderabad, people from northeast India continue to face racism and exclusion. And this has increased post Covid, reveals a new research paper authored by two professors at the University of Hyderabad (UoH). Their paper has been published in Scopus, an online database of scientific work by experts. In the wake of the findings, social organisations from Hyderabad have urged the Telangana govt to follow in the footsteps of Delhi and set up a Special Police Unit for North Eastern Region (SPUNER) to help people from northeast India register their grievances regarding racism and exclusion. IPL 2025 mega auction IPL Auction 2025: Who got whom IPL 2025 Auction: Updated Full Team Squads Researchers also stressed the need for an anti-racial bill to address discriminatory incidents. Apart from being differentiated for their physical features and food choices, the research paper states that many are also denied rented accommodation in the metro city. And the assumptions about people are numerous: That they belong to either China or Nepal, eat dog meat and that the women, working in Hyderabad, are "agents of western and modern culture who pollute the local culture". "Because of this discrimination, many have left their jobs in the city and either returned to their hometowns or relocated to other cities. If the govt is committed towards creating a safe space for people from across India, it must set up this special cell headed by an IPS officer," said Kalamthai George Phaomei, president, Rongmei Organisation Hyderabad. Members of other groups like the Hyderabad Assam Association, Hyderabad Manipuri Society, Naga Christian Fellowship Hyderabad, and Hyderabad Mizo Christian Fellowship, also made a similar appeal. The SPUNER is a unit of the Delhi Police that works to ensure safety and security of people from the northeastern states, Ladakhis, and Gorkhas of Darjeeling who live in Delhi. It has been set up to protect them against unfair treatment through various forms of discrimination, including direct and indirect harassment, segregation, and address the problem of prejudices. Currently, Hyderabad is home to around 50,000 people from eight northeastern states. The Assamese community alone comprises more than 10,000 people. "There is also a pressing need to bring in an anti-racial bill to address discriminatory incidents," said Ajailiu Niumai, professor at the Centre for Study of Social Exclusion & Inclusive Policy, UoH who wrote the paper along with MN Rajesh, an assistant professor from the department of history, UoH. The paper was written based on field surveys conducted across Gachibowli, Panjagutta, Nandi Nagar in Banjara Hills, and BS Makta in Kundanbagh – areas where the majority of them live. "Though the ministry of home affairs prohibited the use of ethnic slurs like ‘chinky' and made it punishable under the anti-racism law in 2012, this is a regular affair. And it is only increasing. We need strict legislation to arrest this," said Janice from Manipur, living in Gachibowli.Rico Carty, who won the 1970 NL batting title when he hit a major league-best .366 for the Atlanta Braves, has died. He was 85. Major League Baseball , the players' association and the Braves paid tribute to Carty on social media on Sunday. No further details on Carty's death were provided. “Carty was one of the first groundbreaking Latino stars in the major leagues, and he established himself as a hero to millions in his native Dominican Republic, his hometown of San Pedro de Macoris, and the city of Atlanta, where he was a beloved fan favorite,” the players' association said in its statement . The Braves said Carty left an indelible mark on the organization. “While his on-field accomplishments will never be forgotten, his unforgettable smile and generous nature will be sorely missed,” the team said in its statement. Carty made his big league debut with the Braves in September 1963. He batted .330 with 22 homers and 88 RBIs in his first full season in 1964, finishing second to Dick Allen in voting for NL Rookie of the Year. The Braves moved from Milwaukee to Atlanta after the 1965 season, and Carty got the franchise's first hit in its new home on April 12, 1966, against Pittsburgh. Carty had his best year in 1970, batting .366 with 25 homers and a career-best 101 RBIs. He started the All-Star Game after he was elected as a write-in candidate, joining Willie Mays and Hank Aaron in the NL outfield. Carty batted .299 with 204 homers and 890 RBIs over 15 years in the majors, also playing for Cleveland, Toronto, Oakland, Texas and the Chicago Cubs. He retired after the 1979 season. AP MLB: https://apnews.com/hub/MLB

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EUGENE, Ore. (AP) — JuJu Watkins scored 21 points to lead No. 6 Southern California to a 66-53 win over Oregon in the Big Ten opener for both teams on Saturday. Watkins was 6 for 15 from the field, including 3 of 9 on 3-pointers, in 28 minutes before fouling out. Kiki Iriafen added 17 points and 12 rebounds for the Trojans (8-1, 1-0 Big Ten). Deja Kelly scored 16 points and Peyton Scott added 13 to lead the Ducks (7-3, 0-1). Oregon led 13-12 after the first quarter, but USC scored the first 18 points of the second quarter and never trailed again. The Trojans built the lead to 40-19 at halftime with 15 points from Watkins. Scott opened the third quarter with four straight points, but USC scored five straight points right after and kept the lead in double digits the rest of the way. USC: The Trojans won their fourth straight since a loss to No. 10 Notre Dame. USC returns to nonconference play over the next three weeks, including a trip to No. 2 UConn. Oregon: The Ducks started the season 6-0 and moved up to No. 23 in the AP poll but have now lost three of four games. Kelly scored to put Oregon up 13-12 early, but USC held the Ducks scoreless for more than five minutes to start the second quarter while scoring 18 straight points. Watkins had a seven-point run of her own within that span. USC outrebounded Oregon 45-31, including 34 defensive rebounds. The Trojans are averaging nearly 12 more rebounds per game than their opponents on the season. USC hosts Fresno State on Tuesday night, and Oregon hosts Air Force on Dec. 17. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here. AP women’s college basketball: https://apnews.com/hub/ap-top-25-womens-college-basketball-poll and https://apnews.com/hub/womens-college-basketballSurprised by Shaq Barrett unretirement, Mike McDaniel says he need to talk to Chris Grier - NBC SportsERIE, Pa. (AP) — Alex Chaikin's 20 points off of the bench helped Lafayette to a 77-73 victory against Mercyhurst on Saturday. Chaikin went 7 of 8 from the field (6 for 7 from 3-point range) for the Leopards (5-5). Justin Vander Baan added 13 points while shooting 3 of 5 from the field and 7 for 9 from the line while he also had six rebounds and five blocks. Andrew Phillips had 10 points and shot 4 of 6 from the field and 1 for 3 from the line. Shemar Rathan-Mayes finished with 21 points and four assists for the Lakers (5-6). Aidan Reichert added 18 points, six rebounds and three steals for Mercyhurst. Jeff Planutis also recorded 13 points. Chaikin scored nine points in the first half and Lafayette went into the break trailing 38-31. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

India's IPO market has seen an unprecedented surge this year, but another interesting trend in this realm this year is that there have been a number of big ticket IPOs, with issue sizes upwards of over Rs 8,000 crore. An analysis by ETMarket of four IPOs upwards of Rs 8,000 crore reveals that the rewards have been mixed. Public offers from Hyundai , Swiggy , NTPC Green and Vishal Mega Mart were among the most anticipated issues to be launched this year, generating a lot of interest from market participants. Among these, three of them — Swiggy, NTPC Green and Vishal Mega Mart — had a decent run after the listing, while Hyundai continues to disappoint investors. !function(){"use strict";window.addEventListener("message",(function(a){if(void 0!==a.data["datawrapper-height"]){var e=document.querySelectorAll("iframe");for(var t in a.data["datawrapper-height"])for(var r=0;r

Rico Carty, who won the 1970 NL batting title when he hit a major league-best .366 for the Atlanta Braves, has died. He was 85. Major League Baseball , the players' association and the Braves paid tribute to Carty on social media on Sunday. No further details on Carty's death were provided. “Carty was one of the first groundbreaking Latino stars in the major leagues, and he established himself as a hero to millions in his native Dominican Republic, his hometown of San Pedro de Macoris, and the city of Atlanta, where he was a beloved fan favorite,” the players' association said in its statement . The Braves said Carty left an indelible mark on the organization. “While his on-field accomplishments will never be forgotten, his unforgettable smile and generous nature will be sorely missed,” the team said in its statement. Carty made his big league debut with the Braves in September 1963. He batted .330 with 22 homers and 88 RBIs in his first full season in 1964, finishing second to Dick Allen in voting for NL Rookie of the Year. The Braves moved from Milwaukee to Atlanta after the 1965 season, and Carty got the franchise's first hit in its new home on April 12, 1966, against Pittsburgh. Carty had his best year in 1970, batting .366 with 25 homers and a career-best 101 RBIs. He started the All-Star Game after he was elected as a write-in candidate, joining Willie Mays and Hank Aaron in the NL outfield. Carty batted .299 with 204 homers and 890 RBIs over 15 years in the majors, also playing for Cleveland, Toronto, Oakland, Texas and the Chicago Cubs. He retired after the 1979 season. AP MLB: https://apnews.com/hub/MLB

Kunlavut and Pornpawee march into quarter-finals

I decided not to study abroad in college because I wanted to stay with my boyfriend on campus. It was my sliding doors moment.Time To Focus On Building A Water-Resilient Global EconomyEmboldened by the view from the top of the NFC North, the Detroit Lions are out to eliminate nightmare holiday gatherings when the Chicago Bears come to town Thursday for a lunchtime division duel. The Lions (10-1) are streaking one direction, the Bears (4-7) the other in the first matchup of the season between teams on opposite ends of the division. Riding a nine-game winning streak, their longest since a 10-game streak during their first season in Detroit in 1934, the Lions are burdened by losses in their traditional Thanksgiving Day game the past seven seasons. Three of the defeats are courtesy of Chicago. The Bears and Lions get together for the 20th time on Thanksgiving -- the Bears have 11 wins -- this week in the first of two meetings between the teams in a 25-day span. Detroit goes to Soldier Field on Dec. 22. "I think there's two things," Campbell said of the Thanksgiving losing streak. "Number one -- Get a W. And it's a division win that's why this huge. Number two is because the players are going to get a couple of days off. So, they have family, friends in, it'd be nice to feel good about it when you're with everybody because it's just not real fun. It's not real fun to be around." Detroit (10-1) owns the best record in the NFC but the Lions aren't even assured of a division title. Minnesota sits one game behind them and Green Bay is two games back. The Bears (4-7) sit in last place and would likely need to run the table to have any chance of making the playoffs. The Lions have been dominant in all phases and haven't allowed a touchdown in the past 10 consecutive quarters. Detroit's offense ranks first in points per game (32.7) and second in total yardage (394.3) The Lions defense has not given up a touchdown in the last 10 quarters. Rookie placekicker Jake Bates has made all 16 of his field goal attempts, including four from 50-plus yards over the past three games. Chicago shows up in a foul mood. The Bears are saddled with a five-game losing streak and Chicago's defense has been destroyed for nearly 2,000 total yards in the last four games. The Bears failed to reach the 20-point mark four times in five outings since they last won a game. In their latest defeat, rookie quarterback Caleb Williams and the offense perked up but they lost to Minnesota in overtime, 30-27. "We have to play complementary football for us to be able to win these games," coach Matt Eberflus said. "The games we have won, we have done that. The games we have been close we've missed the mark a little bit. Over the course of the year, it's been one side or the other, this side or that side. In this league you have to be good on all sides to win. That's what we are searching for." Williams threw for 340 yards and two touchdowns without an interception. The wide receiver trio of DJ Moore, Keenan Allen and Romeo Odunze combined for 21 receptions and two touchdowns while tight end Cole Kmet caught seven passes. "What I've been impressed with is just how he has grown," Campbell said. "He has grown every game but these last two I really feel like he's taken off and what they're doing with him has been really good for him and he just looks very composed. He doesn't get frazzled, plays pretty fast, and he's an accurate passer, big arm, and he's got some guys that can get open for him." Detroit's banged-up secondary could be susceptible against the Bears' veteran receivers in their bid to pull off an upset on Thursday. The Lions put two defensive backs on injured reserve in the past week and top cornerback Carlton Davis isn't expected to play due to knee and thumb injuries. Detroit offensive tackle Taylor Decker (knee) and top returner Kalif Raymond (foot) are also expected to miss the game, though Campbell expressed optimism that running back David Montgomery (shoulder), formerly of the Bears, would play. Bears safety Elijah Hicks was listed as a DNP for Tuesday's walkthrough. --Field Level MediaArticle content One momentary lapse of reason was a contributing factor in the Hounds 3-0 loss to the Kitchener Rangers on Friday night. Soo captain Caeden Carlisle earned a five-minute major for boarding and a game misconduct for his crosscheck into the back of Rangers d-man Alexander Bilecki at 7:56 of the first period. The hit started a minor skirmish behind the Rangers net as players from both teams arrived at the collision point. Justin Cloutier also picked up a minor for roughing. “Yeah. I think so,” said assistant coach Brendan Taylor when asked if the penalty was the turning point of the game. “I felt (the penalty) was unnecessary, and it put us in a tough spot, both because it put us down to five defencemen for 50-plus minutes, but also, because he is our captain and leader, an excellent player and we need him on the ice.” Carlisle was suspended back in October for a check from behind hit against the Sarnia Sting. The Soo captain earned a two-game suspension for his actions. All five-minute major penalties are reviewed for potential suspensions. According to the official OHL scoresheet, Carlisle is in the starting lineup for Saturday’s game in Owen Sound against the Attack. “I thought (the momentum of the game) turned from there,” Taylor said. “It zapped us of energy, and it is something that can’t happen to someone we really need on our team. He does so much for us, and we need him on the ice.” Charlie Schenkel gets the nod in the net. His last start was Nov. 22 against the Erie Otters. Puck drop is 7 p.m. from the Harry Lumley Bayshore Community Centre. The Hounds were shutout for the third time this season. Kitchener goaltender Jackson Parsons has a 120-minute shutout streak against the Soo. He picked up a shutout on Nov. 8 as the Rangers won 4-0. Parsons stopped 20 pucks back in November and stopped 27 last night. Taylor didn’t think his club made life difficult for the soon-to-be Clarkson Golden Knight. “I don’t think we generated enough or made it hard enough on Parsons, who is an excellent goalie,” Taylor said. “I don’t think we got to the net enough and when we did have chances, it looked rushed, a lot of shots on the logo or fanning on them. There was opportunity to have more scoring chances and better, but we didn’t generate nearly enough, not nearly enough offensively in the interior or around the net.” For the second game running, Landon Miller was busy in the net. Miller earned his first shutout of the season in Wednesday night’s 2-0 victory over the Saginaw Spirit. He stopped 38 shots mid-week and turned aside 45 pucks on Friday night. “I thought it was as competitive or more competitive than I have ever seen him,” Taylor said. “Not to say that he normally isn’t, but there were a lot of goal-mouth scrambles where he didn’t give up on a single puck. He was outstanding and so competitive.” Taylor has seen tremendous growth in the young goaltender in the one-plus seasons he’s been an assistant coach with the team. Taylor is excited about Miller’s future in the league, but did warn the lanky netminder is not a finished product quite yet. “It is very difficult to become a starting goaltender in the OHL,” Taylor said. “I think there is a process with lots of ups and downs, trying to establish yourself. Miller is in the process of doing that, and there are still going to be growing pains, but I think the last two games specifically, if he is able to continue and grow from these situations. His confidence should be growing and keep.” Noel Nordh, Brady Martin, Christopher Brown and Spencer Evans were scratched ... John Dean’s two-game suspension is complete. Dean was also fined $1,000. The Soo bench boss ripped into the officials last Saturday night as an interference major assessed to Brady Martin resulted in the game-winning goal late in the third. Martin has one game remaining in his three-game suspension for his hit on Nolan Laird of the North Bay Battalion ... Greyhounds draft choice Noah Tegelaar made the Team East Canada roster for the upcoming Hockey Canada Junior A Challenge. The Hounds drafted Tegelaar in the 2023 U18 draft from the Guelph Gryphons. The Georgetown, Ont., resident is 11-2-1-1 with the Collingwood Blues of the GOJHL this season. Tegelaar played for the Blind River Beavers last year, Share this Story : Rinkside: 'We need (Caeden Carlisle) on the ice,' Hounds lose 3-0 to the Kitchener Rangers Copy Link Email X Reddit Pinterest LinkedIn Tumblr

AUSTIN PEAY 62, GEORGIA STATE 50Trump isn't back in office but he's already pushing his agenda and negotiating with world leadersFirst Advantage: Larger Scale Doesn't Mean Much If Growth Is Poor

FAIRFAX, Va. (AP) — Brayden O'Connor's 17 points helped George Mason defeat Tulane 76-64 on Saturday. O'Connor went 7 of 10 from the field for the Patriots (7-3). Darius Maddox shot 4 for 11 (3 for 6 from 3-point range) and 6 of 6 from the free-throw line to add 17 points. Jalen Haynes shot 4 of 11 from the field and 7 of 9 from the free-throw line to finish with 15 points. Rowan Brumbaugh led the way for the Green Wave (4-6) with 12 points and four assists. Gregg Glenn III added 11 points and 11 rebounds for Tulane. Mari Jordan also had 11 points. George Mason took the lead with 14:04 left in the first half and never looked back. O'Connor led their team in scoring with 15 points in the first half to help put them up 45-27 at the break. George Mason was outscored by Tulane in the second half by a six-point margin, but still wound up on top, while Haynes led the way with a team-high 10 second-half points. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .