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WASHINGTON — President Joe Biden kicked off his final holiday season at the White House on Monday by issuing the traditional reprieve to two turkeys who will bypass the Thanksgiving table to live out their days in southern Minnesota. Biden welcomed 2,500 guests to the South Lawn under sunny skies as he cracked jokes about the fates of “Peach” and “Blossom” and sounded wistful tones about the last weeks of his presidency after a half-century in Washington power circles. “It’s been the honor of my life. I’m forever grateful,” Biden said, taking note of his impending departure on Jan. 20, 2025. That's when power will transfer to Republican President-elect Donald Trump, the man Biden defeated four years ago and was battling again until he was pressured to bow out of the race amid concerns about his age and viability. Biden is 82. Until Inauguration Day, the president and first lady Jill Biden will continue a busy run of festivities that will double as their long goodbye. The White House schedule in December is replete with holiday parties for various constituencies, from West Wing staff to members of Congress and the White House press corps. Biden relished the brief ceremony with the pardoned turkeys, named for the official flower of the president's home state of Delaware. “The peach pie in my state is one of my favorites,” he said during remarks that were occasionally interrupted by Peach gobbling atop the table to Biden's right. “Peach is making a last-minute plea,” Biden said at one point, drawing laughter from an overflow crowd that included Cabinet members, White House staff and their families, and students from 4H programs and Future Farmers of America chapters. Biden introduced Peach as a bird who “lives by the motto, ‘Keep calm and gobble on.’” Blossom, the president said, has a different motto: “No fowl play. Just Minnesota nice.” Peach and Blossom came from the farm of John Zimmerman, near the southern Minnesota city of Northfield. Zimmerman, who has raised about 4 million turkeys, is president of the National Turkey Federation, the group that has gifted U.S. presidents Thanksgiving turkeys since the Truman administration after World War II. President Harry Truman, however, preferred to eat the birds. Official pardon ceremonies did not become an annual White House tradition until the administration of President George H.W. Bush in 1989. With their presidential reprieve, Peach and Blossom will live out their days at Farmamerica, an agriculture interpretative center near Waseca in southern Minnesota. The center's aim is to promote agriculture and educate future farmers and others about agriculture in America. Separately Monday, first lady Jill Biden received the official White House Christmas tree that will be decorated and put on display in the Blue Room. The 18.5 foot (5.64 meters) Fraser fir came from a farm in an area of western North Carolina that recently was devastated by Hurricane Helene . Cartner’s Christmas Tree Farm lost thousands of trees in the storm “but this one remained standing and they named it ‘Tremendous’ for the extraordinary hope that it represents,” Jill Biden said at the event. The Bidens also traveled to New York City on Monday for an evening “Friendsgiving” event at a Coast Guard station on Staten Island. Biden began his valedictory calendar Friday night with a gala for hundreds of his friends, supporters and staff members who gathered in a pavilion erected on the South Lawn, with a view out to the Lincoln Memorial. Cabinet secretaries, Democratic donors and his longest-serving staff members came together to hear from the president and pay tribute, with no evidence that Biden was effectively forced from the Democratic ticket this summer and watched Vice President Kamala Harris suffer defeat on Nov. 5. “I’m so proud that we’ve done all of this with a deep belief in the core values of America,” said Biden, sporting a tuxedo for the black-tie event. Setting aside his criticisms of Trump as a fundamental threat to democracy, Biden added his characteristic national cheerleading: “I fully believe that America is better positioned to lead the world today than at any point in my 50 years of public service.” The first lady toasted her husband with a nod to his 2020 campaign promise to “restore the soul of the nation,” in Trump’s aftermath. With the results on Election Day, however, Biden’s four years now become sandwiched in the middle of an era dominated by Trump's presence on the national stage and in the White House. Even as the first couple avoided the context surrounding the president's coming exit, those political realities were nonetheless apparent, as younger Democrats like Maryland Gov. Wes Moore , Illinois Gov. J.B. Pritzker and Biden's Secretary of Transportation Pete Buttigieg not only raised their glasses to the president but held forth with many attendees who could remain in the party's power circles in the 2028 election cycle and beyond. ___ Associated Press writer Steve Karnowski in Minneapolis contributed to this report.CHICAGO (AP) — Mark Scheifele snapped a third-period tie and Kyle Connor had two assists, helping the Winnipeg Jets beat Chicago 4-2 on Saturday in the first game for interim Blackhawks coach Anders Sorensen. Mason Appleton had a goal and an assist as the Jets picked up their second straight win after a four-game losing streak. Nino Niederreiter and Gabriel Vilardi also scored, and Connor Hellebuyck made 12 saves. Sorensen was promoted from the team’s top minor league affiliate when Luke Richardson was fired on Thursday. Alex Vlasic scored for the second straight game for Chicago, which has dropped five in a row. Alec Martinez added his first goal of the season. The Blackhawks had a 2-1 lead before Niederreiter converted a backhander 13:10 into the second, beating Arvid Soderblom. It was Niederreiter’s 10th of the season. Soderblom entered 11 minutes into the game when Petr Mrazek appeared to aggravate a right groin pull. Appleton had an empty-net goal with 1:41 to play. TAKEAWAYS Jets: Winnipeg outplayed Chicago in the final 30 minutes, not only in shots but in puck possession. Blackhawks: Chicago played with more pace but it still struggled to get the puck to the net. They had only 14 shots on goal. KEY MOMENT Scheifele beat Jason Dickinson on the faceoff that led to Winnipeg’s go-ahead goal. He slid the puck to Connor, then raced to the net for the rebound at 10:18. KEY STAT Blackhawks coaches, interim or full-time, are 6-7-1 in their first game behind the bench since the beginning of the 1995-96 season. Richardson lost his debut at the beginning of the 2022-23 season. UP NEXT Jets: Begin a four-game homestand against the Columbus Blue Jackets on Sunday. Blackhawks: Visit the New York Rangers on Monday night. ___ AP NHL:

N ew electric delivery trucks advances progress towards net-zero goal by 2040 MONTREAL , Nov. 25, 2024 /CNW/ - Labatt Breweries of Canada has acquired 10 new battery-powered trucks for its logistics operations in Quebec . The purchase is the largest single order of VNR Electric trucks for Volvo Trucks in Canada , representing nearly 25 per cent of their deliveries. Labatt's latest investment is in addition to the recent announcement of the purchase of it's first zero-emission mobile service repair truck for the province. "Integrating electric trucks into our fleet marks a significant milestone for our operations and our goal to deliver beer to our customers in the most efficient way possible," said Sarah Genetti , Senior Director of Procurement and Sustainability at Labatt Breweries of Canada . "This initiative is one additional step toward our global ambition of achieving net-zero emissions across our business by 2040 and reflects our commitment to adopting innovative solutions that reduce our carbon footprint." Labatt's $5,470,000 investment in the new electric truck fleet was supported by a $750,000 contribution from the Government of Canada through it's Incentives for Medium- and Heavy-Duty Zero-Emissions Vehicles (iMHZEV) program while the Government of Quebec contributed $875,000 as part of the Écocamionnage "Part 1 – Acquisition of technologies" program. "Electrifying transportation is a powerful way to tackle climate change," said the Honourable Steven Guilbeault, Minister of Environment and Climate Change. "By integrating electric vehicles, companies like Labatt are taking meaningful steps to reduce their ecological footprint—efforts that deserve recognition and encouragement." Each electric truck eliminates the emissions of approximately six conventional vehicles*. The new fleet will achieve a total reduction in emissions equivalent to that of 60 cars. The Volvo VNR Electric trucks offer a range of up to 280 km with four battery packs of 300 kWh of usable energy. They deliver a power output of 340 kWh, equating to 455hp, with a maximum torque of 4,051 lb./ft. Additionally, they feature a towing capacity of 80,000 lbs GCWR (gross combination weight rating). At the Labatt Montreal distribution centre, where each vehicle averages 50 km daily and at the Bois-des-Filion distribution centre, where they average 110 km daily, the new electric trucks are supported by extensive onsite charging infrastructure. Montreal has three single-port and two dual-port ABB Terra 54 and Terra 124 stations, while Bois-des-Filion has one single-port and two dual-port stations. Labatt's delivery teams have received extensive training to operate the recently purchased electric battery vehicles effectively and driver feedback has been very positive, noting the ease of driving, excellent cabin visibility and the quiet operation of the trucks. About Labatt Breweries of Canada Labatt Breweries of Canada is one of Canada's most established businesses and its leading beverage company, with over 3,500 employees, an unmatched portfolio of more than 70 quality products including Budweiser, Busch, Corona, Michelob ULTRA, NÜTRL and Bud Light, six key breweries and four craft breweries from coast-to-coast. Our employees are the driving force behind our business – brewing the world's most loved beverages, building iconic brands and creating meaningful experiences for Canadians. Through 177 years of brewing excellence, we are always looking to serve up new ways to meet life's moments, dream big to move our industry forward and make a meaningful impact in our communities through a collective purpose of creating A Future with More Cheers. About Volvo Trucks North America Volvo Trucks North America , headquartered in Greensboro, North Carolina , is one of the leading heavy-duty truck manufacturers in North America . Its Uptime Services commitment is delivered by a network of nearly 400 authorized dealers across North America and the 24/7 Volvo Trucks Uptime Center. Every Volvo truck is assembled in the Volvo Trucks New River Valley manufacturing facility in Dublin, Virginia , which meets the internationally recognized ISO 9001 standard for quality, 14001 standard for environmental care and holds a dual ISO 50001/Superior Energy Performance certification at the platinum level, indicating a sustained excellence in energy management. Volvo Trucks North America provides complete transport solutions for its customers, offering a full range of diesel, alternative-fuel and all-electric vehicles, and is part of the Volvo Trucks global organization. Volvo Trucks supplies complete transport solutions for discerning professional customers with its full range of medium- and heavy-duty trucks. Customer support is provided via a global network of dealers with 2,200 service points in about 130 countries. Volvo trucks are assembled in 12 countries across the globe. In 2023 approximately 145,000 Volvo trucks were delivered worldwide. Volvo Trucks is part of the Volvo Group, one of the world's leading manufacturers of trucks, buses, construction equipment and marine and industrial engines. The group also provides complete solutions for financing and service. Volvo Trucks' work is based on the core values of quality, safety and environmental care. *Sources: Labatt Internal Truck Usage Data and EPA Greenhouse Gas Emissions from a Typical Passenger Vehicle SOURCE Labatt Breweries of Canada

A sore Mitch Marsh is set to be eased into the second Test against India in Adelaide as Australia attempt to bounce back from their series-opening flop in Perth. India lead the five-Test Border-Gavaskar series 1-0 after crushing Australia by 295 runs inside four days at Perth Stadium. Test skipper Pat Cummins has hinted Australia are likely to retain the same XI for the pink ball Test in Adelaide despite their woeful batting display in Perth. Know the news with the 7NEWS app: Download today Marnus Labuschagne is under the most heat after posting two off 52 balls in the first innings before making three in the second dig. Debutant Nathan McSweeney (10, 0), Usman Khawaja (eight, four) and Steve Smith (0, 17) are others who are desperate for a big score. Marsh has barely bowled this year due to a series of niggles, but he racked up 17 overs across two innings in Perth. The 33-year-old picked up 2-12 off five overs in India’s first innings, before toiling for 1-65 off 12 in the second innings as the visitors declared at 6-487. Marsh then made 47 off 67 balls on Monday in Australia’s total of 238. With Cameron Green (back) ruled out for the summer, Marsh’s bowling is crucial for Australia as the hosts attempt to ease the load on quicks Cummins, Mitchell Starc and Josh Hazlewood. Marsh pulled up sore from the Perth Test, but he at least has a 10-day break before the day-night clash in Adelaide. Cummins hopes Marsh will be able to bowl in each Test match he plays this summer, but his body will be closely monitored in the lead-up to Adelaide. “He’s (been) battling a couple of little niggles since the UK tour,” Cummins said. “So the main thing is he’s in there as one of the top six batters in the country and bowling is a bonus. “He was a little bit sore towards the end of this Test match. “In the next 10 days, chance to freshen up try and get it right. We’ll see how he goes. Ideally, he would be able to bowl in each Test match.” Australia last won a Border-Gavaskar series in 2014-15, with India holding the trophy since 2017. India are aiming to beat Australia at home for a third consecutive series. The last time Australia recovered from a 1-0 deficit and came back to win a Test series was in the 1997 Ashes in England. With the Test match in Perth finishing in four days, Cummins said the team was likely to arrive in Adelaide a day earlier than first planned. Cummins is confident his team will quickly adapt to the pink ball. “No doubt the batters will want at least one hit in daylight and night time,” Cummins said. “And same with fielding — we’ll catch some balls under lights and do a fielding session during the day. “It’s just a little bit different to pick up with the eye. As a bowler it feels a little bit different. “But one or two sessions — we’ve played a lot with pink balls, so it’s not as big an adjustment for us.” LIVE, FREE AND ON DEMAND: Watch Australia v India on Seven and 7plus Sport‘Disrespecting the game’: Legend calls for India to ‘have a little word’ with fiery quick after Head send-offNASSAU, Bahamas — Justin Thomas was long off the tee and made a few long putts on the back nine to overtake Scottie Scheffler with a 6-under 66 and build a one-shot lead Saturday over golf's best player going into the final round of the Hero World Challenge. Thomas is trying out a 46-inch driver — a little more than an inch longer than normal — that he previously used for practice at home to gain speed and length. He blasted a 361-yard drive to 8 feet on the par-4 seventh hole and led the field in driving distance. But it was a few long putts that put him ahead of Scheffler, who had a 69. Thomas was on the verge of falling two shots behind when he made an 18-foot par putt on the par-3 12th hole. On the reachable par-4 14th, he was in a nasty spot in a sandy area and could only splash it out to nearly 50 feet. He made that one for a most unlikely birdie, while behind him Scheffler muffed a chip on the 13th hole and made his lone bogey of a windy day. Scheffler never caught up to him, missing birdie chances on the reachable 14th and the par-5 15th. Thomas hit his approach to 3 feet for birdie on the 16th after a 343-yard drive. Scheffler made an 18-foot birdie putt on the 16th to close within one. Scheffler missed birdie chances on the last two holes from the 10-foot and 15-foot range, while Thomas missed an 8-foot birdie attempt at the last. “I had a stretch at 13, 14, 15 where I felt like I lost a shot or two there, but outside of that I did a lot of really good things today,” Scheffler said. Thomas hasn't won since the 2022 PGA Championship at Southern Hills, and a victory at Albany Golf Club wouldn't count as an official win. But the two-time major champion has made steady progress toward getting his game back in order. “I'm driving it great. I've had a lot of confidence with it,” Thomas said of his longer driver. “I feel like I've been able to put myself in some pretty good spots going into the green. I’m still not taking advantage of some of them as much as I would like, but that’s golf and we're always going to say that.” Thomas was at 17-under 199 and will be in the final group Sunday with Scheffler, who is trying to end his spectacular season with a ninth title. Tom Kim put himself in the mix, which he might not have imagined Thursday when he was 3 over through six holes of the holiday tournament. Kim got back in the game with a 65 on Friday, and then followed with 12 birdies for a 62. He had a shot at the course record — Rickie Fowler shot 61 in the final round when he won at Albany in 2017 — until Kim found a bunker and took two shots to reach the green in making a double bogey on the par-3 17th. Even so, he was only two shots behind. Ryder Cup captain Keegan Bradley (68) was four back. “Feel like I’ve been seeing signs of improvement, which is what you want and that’s all I can do,” Thomas said. “I can’t control everybody else or what’s going on, I’ve just got to keep playing as good as I possibly can and hope that it’s enough come Sunday.”

Spurs Have No-Flight Zone in 'Area 51'MIAMI — President-elect Donald Trump won Miami-Dade County in a landslide, but will that be enough to get a street named after him? Hialeah wants Miami-Dade to recognize the city’s creation of President Donald J. Trump Avenue, a request that’s on the County Commission’s Dec. 3 agenda. The item would force Democrats on the County Commission, which is officially nonpartisan, to decide whether to support honoring the incoming Republican president. Democrats hold seven of the 13 commission seats, but Trump won 10 of the commission districts in November on his way to an overall victory in Miami-Dade. After losing Miami-Dade in 2016 and 2020, Trump last month became the first Republican presidential candidate to win the former Democratic stronghold since George H.W. Bush in 1988 . He beat Vice President Kamala Harris by 11 points, taking 55% of the vote in Miami-Dade. “I think President Trump is very worthy of this honor as our 45th and 47th president,” said the item’s sponsor, Miami-Dade Commissioner Kevin Cabrera, a Republican. “I think our community clearly has overwhelming support for him based on the results of this last November.” Hialeah city commissioners voted last year to turn Palm Avenue into President Donald J. Trump Avenue, a change that would let City Hall add the incoming president’s name to letterhead. “All of our correspondence will have 501 President Donald J. Trump Avenue,” Hialeah Mayor Esteban Bovo said, referring to City Hall’s longtime address of 501 Palm Ave. Bovo said he doesn’t want to remove Palm Avenue from city geography and that the portion already named Veterans Way would not be replaced by the Trump tribute. Instead, he said he’s planning for the Trump Avenue signs to go up as new additions on the thoroughfare and become the preferred name for city government. Naming roadways after political figures isn’t new in Miami-Dade. In 2016, the County Commission approved a request by Miami Gardens to recognize part of the city’s Northwest 185th Terrace as President Barack and Michelle Obama Boulevard. Sharing room on the Dec. 3 agenda with the Trump naming proposal is another Miami Gardens request to honor a Democratic office holder by adding Rep. Frederica Wilson’s name to Northwest 47th Avenue. Because Florida controls that avenue, the legislation calls for Miami-Dade to join Miami Gardens in lobbying Florida to honor Wilson. When the requests go to Miami-Dade, they’re officially “co-designations,” meaning the Trump, Wilson and Obama names are added to existing street names in the county’s register of roadways rather than replacing them. For Trump, the novelty will likely come in the paperwork. A 2019 rule change by the County Commission requires background reports for any would-be honoree, setting up the possibility of commission auditors detailing Trump’s May conviction in New York related to hush-money allegations, as well as two federal cases against him, including one tied to President-elect Trump’s attempt to overturn the 2020 presidential election and prevent Joe Biden from taking office. Federal prosecutors said Monday that case is being dropped as Trump prepares to take office, while a judge had previously dismissed a Trump case alleging mishandling of classified documents. While renaming county-maintained roads after living federal officials requires a two-thirds vote, approving a request for a city-maintained road only needs majority support on the County Commission. Should the vote break down on party lines, Republicans would need one Democrat to back Trump Avenue. But that assumes a roll call even takes place. If no commissioner requests a separate vote, the Cabrera proposal would just be approved en masse with the other non-contested items on the Dec. 3 agenda. That could let Democrats on the commission avoid a vote dedicated solely to the effusive Trump language in the legislation by Cabrera, a one-time lobbyist who launched his political career in 2022 with a Trump endorsement in that year’s District 6 commission race and now is hoping for a position in the second Trump administration. Among the words of Trump praise in the Cabrera legislation: “the United States thrived under President Trump’s leadership” and “President Trump also worked to restore democracy and the rule of law around the world.” Cabrera said he plans to vote for the Rep. Wilson street naming and would also support adding President Joe Biden’s name to a local roadway if a Miami-Dade municipality requested it. “I think municipalities should have wide latitude for who they name streets after,” he said. To put Trump’s name prominently on signs hanging off of traffic lights and other county infrastructure, Hialeah needs Miami-Dade approval. The city held off requesting that until now, Cabrera said, a delay that may make the politics easier. Along with Trump winning the election, control over the County Commission’s agenda recently shifted to a Republican, with Commissioner Anthony Rodriguez, a Trump supporter, taking over from Democrat Oliver Gilbert, a Harris supporter, as board chair. Gilbert and the other six Democrats on the commission did not respond to requests for comment Monday on the Trump Avenue proposal. Neither did a spokesperson for the county’s Democratic mayor, Daniella Levine Cava. (Miami Herald staff writer Verónica Egui Brito contributed to this report.) ©2024 Miami Herald. Visit at miamiherald.com . Distributed by Tribune Content Agency, LLC.

Long-term in fire-riddled Southern California has been associated with diagnoses of , researchers said Monday. The smoke, which contains a , produces particles known as PM2.5. While the air humans breathe always contains particle pollution, exposure to PM2.5 can affect the lungs and heart. Particle pollution has been linked to in people with related conditions, irregular heartbeat, aggravated asthma, nonfatal heart attacks, decreased lung function and difficulty breathing. It with neurodegenerative diseases, such as dementia. But, understanding the role of PM2.5 sources . Now, in an 11-year study of more than 1.2 million Kaiser Permanente members in Southern California ages 60 and up, a group of doctors from around the country said that rates of dementia rose significantly among residents who had been frequently exposed to wildfire smoke over a . “Wildfires, once rare and geographically confined, now regularly impact populations across the US,” the physicians said. “Anthropogenic climate change has increased wildfire frequency and intensity, eroding gains in air quality achieved under the Clean Air Act in the Western US.” They noted that wildfire-generated particulate matter accounts for the majority of people’s exposure to PM2.5 on poor air quality days in California. The authors said every one-microgram-per-square-meter increase of wildfire-generated air pollution “was associated with an 18 percent increase in the odds of dementia diagnosis.” Those who were under the age of 75 when they entered the study appeared more prone to negative effects compared with people who were older. The link between wildfire smoke and dementia was stronger among participants who were Black and Hispanic. Others were also disproportionately affected including people living in poorer areas and minorities. “These latter findings underscore the importance of research that considers the effects of air pollution on potentially vulnerable population subgroups and aims to identify potential strategies to mitigate inequities in air pollution exposure effects,” researchers wrote. The group said helping to prevent fires and protect the state’s residents from smoke could reduce the risk of dementia and support health equality in the future.” The research was published in the journal . These findings come after California saw its fourth-largest wildfire in history this summer, and red flag warnings and other risks have continued into November and across the drought-covered U.S. A study published earlier in the year found that pollution in smoke produced by has around the world in recent years compared to decades ago. “This indicates that climate change is increasingly posing a threat to public health, driven by more fire smoke even affecting densely populated areas,” Chae Yeon Park, a researcher at the Japanese National Institute of Advanced Industrial Science and Technology and the lead author of the research, said.

New study finds obesity costs US industry $347bn a year - Pharmaceutical TechnologyJudge Grants Dismissal Of Donald Trump's 2020 Election Subversion Case‘There are kids on the estate with potential; we want to give them the opportunity’ – Bransholme club offering free rugby trainingNone

Report: Chargers expect WR Ladd McConkey, LB Khalil Mack to play vs. RavensBy MARC LEVY HARRISBURG, Pa. (AP) — Democratic Sen. Bob Casey of Pennsylvania conceded his reelection bid to Republican David McCormick on Thursday, as a statewide recount showed no signs of closing the gap and his campaign suffered repeated blows in court in its effort to get potentially favorable ballots counted. Casey’s concession comes more than two weeks after Election Day, as a grindingly slow ballot-counting process became a spectacle of hours-long election board meetings, social media outrage, lawsuits and accusations that some county officials were openly flouting the law. Republicans had been claiming that Democrats were trying to steal McCormick’s seat by counting “illegal votes.” Casey’s campaign had accused of Republicans of trying to block enough votes to prevent him from pulling ahead and winning. In a statement, Casey said he had just called McCormick to congratulate him. “As the first count of ballots is completed, Pennsylvanians can move forward with the knowledge that their voices were heard, whether their vote was the first to be counted or the last,” Casey said. The Associated Press called the race for McCormick on Nov. 7, concluding that not enough ballots remained to be counted in areas Casey was winning for him to take the lead. As of Thursday, McCormick led by about 16,000 votes out of almost 7 million ballots counted. That was well within the 0.5% margin threshold to trigger an automatic statewide recount under Pennsylvania law. But no election official expected a recount to change more than a couple hundred votes or so, and Pennsylvania’s highest court dealt him a blow when it refused entreaties to allow counties to count mail-in ballots that lacked a correct handwritten date on the return envelope. Republicans will have a 53-47 majority next year in the U.S. Senate. Follow Marc Levy at twitter.com/timelywriter

Saudi Arabia grants operator license for 1st international marina to Jeddah yacht clubCutting-edge technologies, including state-of-the-art camera networks and facial recognition software powered by artificial intelligence, are being used by police in the hunt for the brazen killer who shot United Healthcare boss Brian Thompson dead in broad daylight on 6th Avenue on Wednesday. They’re just a few of the advanced tools, along with drones, DNA testing and GPS tracking, that the NYPD has at its disposal — and some of these technologies having already proved invaluable in piecing together the moments before, during and after Thompson, 50, was executed on a city street. Hotel surveillance cameras captured the still-at-large gunman waiting patiently outside the New York Hilton Midtown on West 54th Street before he approached his target — the CEO of the health care giant, who was not accompanied by bodyguards — from behind and opened fire at close range just before 7 a.m., killing Thompson. A woman who witnessed the incident close-up can be seen running for her life before the killer appears to calmly leave the scene, sneak through an alley and ride away on an electric bike, disappearing into Central Park. Since then, the police have poured an incredible amount of resources into identifying the assassin and piecing together his movements before the brazen crime. So far, the network of surveillance cameras operated by both the NYPD and private businesses has uncovered a picture of the smiling suspect at the HI New York City Hostel at 891 Amsterdam Ave. on the Upper West Side of Manhattan prior to the slaying. Other footage showed the suspect and his partially hidden face inside a Starbucks near the crime scene, which he visited minutes before the shooting. Police have also collected shell casings from the scene and a phone that the killer left behind. Here is how else technology is aiding police in the manhunt: Facial recognition The NYPD has a dedicated unit, known as the Facial Identification Section, which uses software to compare images from a crime scene or investigation with a database of known individuals, such as mugshots, pistol permit images and gang member photos, Fox Business reports. While facial recognition technology has come a long way in recent years, it’s not like in the movies, according to retired NYPD detective Herman Weisberg. “This man was wearing a mask, which could hinder facial recognition software because it recognizes points in the face and measures the distance between them,” Weisberg, who is now the managing director at private investigations agency Sage Intelligence, told The Post. “The technology is there and fine in a controlled environment like a Las Vegas casino, but it’s less effective on footage shot on a street in low light or bad weather.” Pictures have emerged of the man who police claim is the killer smiling after having pulled his mask down in the hostel where he was staying. However, due to the angle of his head and the fact he was still wearing a hood, it may hamper analysis, sources said. “As far as trailing someone with a gray hoodie and a backpack on a bike, the cameras are so voluminous that if you miss him on one block, you can find him on the next and start canvassing there. “It’s painstaking, tedious work and not as easy as it looks ... but the NYPD has become very good at utilizing the public’s videos for a crime of this magnitude,” Weisberg added. In 2019, the NYPD’s Facial Identification Section received 9,850 requests for comparison, according to its site. Out of those requests, the unit identified 2,510 possible matches for suspects. This includes possible matches in 68 murders, 66 rapes, 277 felony assaults, 386 robberies and 525 grand larcenies. Facial recognition technology is a valuable tool in solving crimes, but it is not by itself enough grounds for an arrest, and must be accompanied by police work, according to the NYPD . Surveillance footage New York has an extensive system of cameras constantly monitoring the city, which police can access. The NYPD also leverages the Domain Awareness System, one of the world’s largest networks of cameras, license plate readers and radiological sensors, designed to detect and prevent terrorist acts but also of great value in criminal investigations, according to its site . The system is reportedly made up of numerous physical and software components, including over 18,000 closed-circuit television cameras. “The NYPD has their own security cameras, especially in Midtown areas and subway stations where there is so much foot traffic. It’s a pretty impressive system with state-of-the-art technology that really gives them the advantage over typical storefront cameras,” Weisberg added. “It’s come a long way compared to the old systems, you have really high-definition cameras that pick up low-light situations, and because they’re operated by the NYPD, they are designed and angled to detect crime and hopefully assist in hunting down people who flee the scene.” In addition to that, dashcams and other cameras fitted to city-owned trucks, buses, cars and, of course, officers themselves are also recording at any given time or place. NYPD Chief of Detectives Joseph Kenny told reporters that police have been “pulling video from numerous locations, numerous sources” in their search for the suspect, who was carrying a “distinctive gray backpack.” With so many cameras in the city — including an abundance of security cameras operated by private businesses — there is likely more footage of the suspect yet to emerge. The NYPD is the most technologically advanced police department in the nation and one of the most advanced in the world, utilizing the most up-to-date technologies. “There’s advancement of all the technology available, whether advanced photographs, resources in being able to retrieve fingerprints, any type of DNA, cellphone records, any technical aspects available today that were not available years ago that helps [investigators],” explained retired NYPD homicide detective Leonard Golino, who is now the owner of private investigative agency Gold Shield Elite. Golino explained that with so many video cameras on every New York City street, building, lobby and subway station, authorities have to narrow down their search. “You need a starting point and [in this case] they have that — with the location and individual on camera, [investigators] then expand out to the area the subject passes through and follow that trajectory. From that point you canvass the area, see what cameras are there, then pull footage and try to match it to the suspect.” GPS tracking , ballistics and DNA testing Law enforcement sources previously said the masked gunman used a silencer and appeared to be an experienced shooter as he pumped bullets into Thompson, of Minnesota, causing him to collapse on the pavement. The gunman’s weapon jammed during the shooting, but the killer swiftly rectified the issue and continued firing as the CEO tried to crawl away, according to security footage. “His ability to clear the jam is about as good as it gets,” Weisberg said. “To have that clarity under that pressure means he kept a cool head and had ample training to clear jams, which every police and military person has and keeps in the back of their head. “He’s definitely done some training at a shooting range at the very least.” After gunning down Thompson, the suspect ran into an alleyway, then jumped on an electric bike, which he rode north along Sixth Avenue into Central Park, where surveillance camera coverage is spotty, police said. Police initially said the shooter rode into Central Park on a bicycle from the city’s bike-share program, CitiBike, but the program’s operator, Lyft, later confirmed that the bike was not one of its machines. Other pieces of evidence being examined include three live 9-millimeter rounds and three discharged casings recovered in front of the Hilton hotel on Sixth Avenue, where Thompson was set to host an investors’ conference that morning. “The crime scene is a critical point at the initial stage of the investigation, especially when you’ve got ballistics that give you information about the weapon and footage that gives you direction of flight,” Golino said. Police also said they found a water bottle and protein bar wrapper from a trash can near the scene of the shooting believed to have been purchased by the suspect minutes before the shooting. DNA evidence has been recovered from those items, sources said. A Starbucks coffee cup allegedly used by the shooter is also being processed for DNA evidence with results expected in days, according to sources. Drones While Central Park entrances and subway stations are fitted with surveillance cameras, there are many blind spots within the park. That’s one reason drones are used by the NYPD to conduct regular patrols in the area and, in some cases, respond to emergencies, such as searching for missing or wanted people. Mayor Eric Adams and police officials last month announced the expansion of the city’s Drone as First Responder (DFR) program, which includes a fleet of 109 drones flown by roughly 60 police officers certified to operate them by the Federal Aviation Administration. “The DFR program will deploy drones to assist with public safety calls, including searches for missing people, alerts from gunshot detection systems, robberies and grand larcenies, and other crimes in progress,” Adams said at a November press conference announcing the expanded program led by NYPD Deputy Commissioner of Operations Kaz Daughtry. “These drones [give] a live feed enabling [officers] to make initial scene assessments.” All of the drones are controlled from a room at police headquarters in Lower Manhattan. “Drones are less costly than helicopters when you’re looking for certain things,” Golino told The Post. “There are different types — heat-sensored or ones that detect movements and can zoom in certain areas or to pick up the subject itself, or something they left behind. It helps the investigation and speeds it up, while giving an overall look of the area from above.” However, alongside all the technology and advanced searching systems, Golino and Weisberg agree there is no substitute for old-fashioned police work, with boots on the ground, talking to people and gathering evidence. “There are lots of pieces and elements to [a manhunt] like this — a lot goes into it. “You just have to take it one step at a time,” Golino added.

Decision follows observations of liver transaminitis without clinically significant symptoms in some subjects on azelaprag Company will evaluate data from patients enrolled to date and share updated plans for azelaprag in Q1 2025 In parallel to evaluating azelaprag, Company will continue to advance earlier platform-derived programs, including IND submission for CNS penetrant NLRP3 inhibitor anticipated in the second half of 2025 RICHMOND, Calif., Dec. 06, 2024 (GLOBE NEWSWIRE) -- BioAge Labs (Nasdaq: BIOA) ("BioAge”, "the Company”), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today announced that the Company has made the decision to discontinue the ongoing STRIDES Phase 2 study of its investigational drug candidate azelaprag as monotherapy and in combination with tirzepatide after liver transaminitis without clinically significant symptoms was observed in some subjects receiving azelaprag. No transaminase elevations were observed in the tirzepatide only treatment group. "Patient safety is our top priority in the conduct of our clinical studies,” said Kristen Fortney, PhD, CEO and co-founder of BioAge. "We made the difficult decision to discontinue the STRIDES Phase 2 study of azelaprag because it became clear that the emerging safety profile of the current doses tested is not consistent with our goal of a best-in-class oral obesity therapy. While this outcome is a significant disappointment, we remain encouraged by azelaprag's promising preclinical and Ph1b efficacy profile. We remain committed to our focus on developing therapies for metabolic aging. In parallel to assessing the next steps for the azelaprag program, we will continue to advance our NLRP3 inhibitor program as well as additional research programs with novel mechanisms emerging from our platform.” STRIDES is a randomized, double-blind, placebo-controlled Phase 2 clinical trial of azelaprag as monotherapy and in combination with tirzepatide that planned to enroll approximately 220 individuals with obesity aged 55 years and older ( link ). The trial was designed to evaluate the efficacy as measured by body weight reduction and other outcomes, safety, and tolerability of two oral doses of azelaprag (300 mg, once or twice daily) in combination with tirzepatide (5 mg subcutaneous injection once weekly). An azelaprag monotherapy arm was included to provide additional safety information. Of 204 subjects enrolled in STRIDES as of today, 11 subjects in the azelaprag treatment groups were observed to have transaminase elevations with no clinically significant symptoms. Dosing of all subjects will be discontinued, and no additional subjects will be enrolled. Clinical follow-up of enrolled subjects will continue off drug. The Company intends to further analyze available STRIDES clinical data from all enrolled subjects. The Company has notified all study investigators and regulatory authorities including the U.S. Food and Drug Administration (FDA) of the Company's decision to discontinue enrollment. The Company intends to share updated plans for azelaprag in Q1 2025. BioAge continues to advance its pipeline of therapeutic candidates targeting the biology of aging to treat metabolic diseases. The Company's novel class of brain-penetrant NLRP3 inhibitors, which have demonstrated high potency and a novel binding site, are progressing toward IND submission, anticipated in the second half of 2025. The NLRP3 inhibitor program targets neuroinflammation, which is linked to both metabolic and neurodegenerative diseases. In addition, BioAge is advancing multiple targets derived from its proprietary discovery platform, which analyzes molecular data spanning over 50 years of human aging trajectories. About BioAge Labs, Inc. BioAge is a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases, such as obesity, by targeting the biology of human aging. BioAge's lead product candidate, azelaprag, is an orally available small molecule agonist of APJ that was observed to promote metabolism and prevent muscle atrophy on bed rest in a Phase 1b clinical trial. BioAge is also developing orally available small molecule brain penetrant NLRP3 inhibitors for the treatment of diseases driven by neuroinflammation. BioAge's preclinical programs, based on novel insights from the company's discovery platform built on human longevity data, address key pathways in metabolic aging. Forward-looking statements This press release contains "forward-looking statements” within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, statements regarding our plans to develop and commercialize our product candidates, our business strategy, results of our ongoing or planned clinical trials, the timing of any future updates to our programs and the clinical utility of our product candidates. These forward-looking statements may be accompanied by such words as "aim,” "anticipate,” "believe,” "could,” "estimate,” "expect,” "forecast,” "goal,” "intend,” "may,” "might,” "plan,” "potential,” "possible,” "will,” "would,” and other words and terms of similar meaning. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including: our ability to develop, obtain regulatory approval for and commercialize our product candidates; the timing and results of preclinical studies and clinical trials; the risk that positive results in a preclinical study or clinical trial may not be replicated in subsequent trials or success in early stage clinical trials may not be predictive of results in later stage clinical trials; risks associated with clinical trials, including our ability to adequately manage clinical activities, unexpected concerns that may arise from additional data or analysis obtained during clinical trials, regulatory authorities may require additional information or further studies, or may fail to approve or may delay approval of our drug candidates; the occurrence of adverse safety events; failure to protect and enforce our intellectual property, and other proprietary rights; failure to successfully execute or realize the anticipated benefits of our strategic and growth initiatives; risks relating to technology failures or breaches; our dependence on collaborators and other third parties for the development of product candidates and other aspects of our business, which are outside of our full control; risks associated with current and potential delays, work stoppages, or supply chain disruptions; risks associated with current and potential future healthcare reforms; risks relating to attracting and retaining key personnel; failure to comply with legal and regulatory requirements; risks relating to access to capital and credit markets; and the other risks and uncertainties that are detailed under the heading "Risk Factors” included in BioAge's Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) on November 7, 2024, and other filings with the SEC filed from time to time. BioAge undertakes no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise. Contacts PR: Chris Patil, [email protected] IR: Elena Liapounova, [email protected] Partnering: [email protected] Web: https://bioagelabs.comTimberwolves may acquire veteran NBA champion to bolster backcourt | Sporting News

Google and the US government faced off in a federal court on Monday, as each side delivered closing arguments in a case revolving around the technology giant's alleged unfair domination of online advertising. The trial in a Virginia federal court is Google's second US antitrust case now under way as the US government tries to rein in the power of big tech.None

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