jilibet 291 OSAKA, Japan and MONTREAL , Dec. 5, 2024 /PRNewswire/ -- Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan ; President: Toichi Takino; "Ono") announced that it has entered into a drug discovery collaboration agreement with Congruence Therapeutics (Headquarters: Montreal, Quebec, Canada ; CEO: Clarissa Desjardins; "Congruence") to generate novel small molecule correctors against multiple protein targets in the oncology area by leveraging Congruence's proprietary drug discovery platform, RevenirTM. Under the terms of the agreement, Congruence will generate small molecule correctors by leveraging Congruence's proprietary drug discovery engine called, RevenirTM. Ono will obtain an exclusive option right to develop, manufacture and commercialize the identified small molecule correctors worldwide. Congruence will be eligible to receive an upfront payment, research expenses, milestone payments based on research and development progress and sales, as well as tiered royalties based on net sales. "We believe that this collaboration with Congruence may help generating novel small molecule correctors for validated targets in the oncology area by leveraging their own technologies in protein dynamics and computational biology, leading to our development pipeline," said Seishi Katsumata , Corporate Officer / Executive Director, Discovery & Research of Ono. "We will be committed to delivering innovative new drugs to cancer patients as soon as possible." "Congruence is thrilled to partner with Ono, which has established itself as a global leader in drug development, particularly in the oncology space. We believe that our RevenirTM platform and capabilities in protein dynamics will accelerate the discovery of novel therapies for compelling targets of interest to both companies," said Sharath Hegde PhD, Chief Scientific Officer of Congruence. About RevenirTM Drug Discovery Platform RevenirTM, Congruence's proprietary computational drug discovery platform, captures the dynamic biophysical changes caused by mutations in proteins, offering unique insights into protein defects and their correction. By examining surface features and a spectrum of biophysical descriptors across an ensemble of protein conformers, RevenirTM predicts small molecule induced correction of the underlying defect. About Congruence Therapeutics Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Congruence's proprietary scalable platform, RevenirTM, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. For more information, please visit www.congruencetx.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/ono-enters-into-drug-discovery-collaboration-agreement-with-congruence-therapeutics-to-generate-novel-small-molecule-correctors-in-the-oncology-area-302324452.html SOURCE Ono Pharmaceutical co., ltd.NEW YORK (AP) — U.S. stocks tiptoed to more records amid a mixed Tuesday of trading, tacking a touch more onto what’s already been a stellar year so far. The S&P 500 edged up by 2 points, or less than 0.1%, to set an all-time high for the 55th time this year. It’s climbed in 10 of the last 11 days and is on track for one of its best years since the turn of the millennium. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Get any of our free email newsletters — news headlines, obituaries, sports, and more.Vance takes on a more visible transition role, working to boost Trump’s most contentious picks

Arcutis Biotherapeutics exec buys $7,766 in stock

Sanoma Corporation, Stock exchange release, 27 December 2024 at 18:30 EET SANOMA CORPORATION: ACQUISITION OF OWN SHARES 27 December 2024 Nasdaq Helsinki Ltd: The share buybacks are executed in compliance with Regulation No. 596/2014 of the European Parliament and Council (MAR) Article 5 and the Commission Delegated Regulation (EU) 2016/1052. The company holds a total of 349,690 of its own shares (SANOMA) including the shares acquired on 27 December 2024. Detailed information concerning the acquisition is attached to this stock exchange release. On behalf of Sanoma Corporation Skandinaviska Enskilda Banken AB (publ) Helsinki branch Antti Salakka Jaakko Kosunen Additional information Kaisa Uurasmaa, Head of Investor Relations and Sustainability, tel. +358 40 560 5601 Sanoma Sanoma is an innovative and agile learning and media company impacting the lives of millions every day. Our Sustainability Strategy is designed to maximise our positive ‘brainprint’ on society and to minimise our environmental footprint. We are committed to the UN Sustainable Development Goals and signatory to the UN Global Compact. Our learning products and services enable teachers to develop the talents of every child to reach their full potential. We offer printed and digital learning content as well as digital learning and teaching platforms for primary, secondary and vocational education, and want to grow our business. Our Finnish media provide independent journalism and engaging entertainment also for generations to come. Our unique cross-media position offers the widest reach and tailored marketing solutions for our business partners. Today, we operate in twelve European countries and employ more than 5,000 professionals. In 2023, our net sales amounted to approx. 1.4bn€ and our operational EBIT margin excl. PPA was 12.6%. Sanoma shares are listed on Nasdaq Helsinki. More information is available at sanoma.com. Attachment SANOMA SBB 27122024

US homelessness up 18% as affordable housing remains out of reach for many people

KARACHI: Chairman of the Pakistan Peoples Party (PPP), Bilawal Bhutto Zardari, on Saturday called for political stability in Pakistan, whether it requires “dialogue between the government and opposition or the use of force”. Speaking at a rally marking the PPP’s 57th founding anniversary in Sukkur, Bhutto highlighted that achieving peace and economic stability in Pakistan required national consensus, underlining that political differences must not hinder the country’s progress. “Political stability is essential for the country’s future, whether achieved through dialogue or, if necessary, through firm measures,” Bhutto stated. He also called for a new National Action Plan (NAP) to combat terrorism, recognising the country’s urgent need to address growing security threats. Bilawal Bhutto urged all political parties and activists to strive for democracy and the supremacy of the constitution in the country, as other issues can only be addressed after achieving political stability. He emphasized that the opposition plays a crucial role in ensuring political stability, as they are not presenting themselves as a democratic and political opposition. Critisizing, PTI for protest and making choas in Islamabad, he mentioned that some political parties in Pakistan are not practicing politics within the political framework. The events of May 9 and what happened in Islamabad are not politics. Politicians must engage in political processes to limit the role of institutions to their constitutional boundaries. Bilawal added that politicians should resolve issues through dialogue. It is his desire that both the government and opposition work together to establish political stability in the country, with the government bearing more responsibility in this regard. He stated that some opposition parties want to engage in political opposition, while others adopt an anti-political and undemocratic approach. The opposition adopting a democratic and political stance should be responded to accordingly. If the opposition continues with an undemocratic stance, the government will respond in the same manner. Bilawal emphasized that they always advocate for negotiations and dialogue, but the opposition parties are seeking talks with the establishment rather than with political parties. If this approach to politics continues, both PTI and the country will suffer. The PPP chairman stated that the government has not contacted him regarding a ban on PTI or the imposition of governor’s rule in Khyber Pakhtunkhwa. If the government reaches out, they will try to ensure a decision is made by consensus. Bilawal said that the situation in Khyber Pakhtunkhwa is very grave, and an emergency crisis is developing due to law and order issues. The situation in Parachinar is being highlighted on social media and international media, while the provincial government is attacking the federation instead of restoring its authority. Bilawal added that the Chief Minister is still threatening to shoot at the federation in the assembly. He questioned how long they would tolerate this, as the real issues of Pakistan are different. “There are over 100 bodies in Khyber Pakhtunkhwa, and they are looking for their 100 bodies in Islamabad.” He further stated that it is the responsibility of the provincial government to restore law and order in Kurram with the help of the federation. If they are not serious about this and only prioritise the release of their leader or securing an NRO, then they should relinquish their provincial government responsibilities. Bilawal expressed hope that the provincial government would acknowledge its mistakes and focus on public issues. He also said that while protest is a right of the people, taking the law into their own hands or engaging in militancy should never be allowed. Bhutto marked the anniversary by addressing PPP workers from 150 regions across Pakistan, including all four provinces, Azad Kashmir, and Gilgit-Baltistan, showcasing the party’s extensive reach. He praised PPP’s continued presence and its role in Pakistan’s political landscape, citing the enduring legacy of its leaders. “Our political journey began with Zulfikar Ali Bhutto, who laid the foundation for democracy in Pakistan and provided a constitutional framework for the country,” he said, honouring the party founder’s legacy. Bhutto also recalled the former prime minister’s role in implementing economic policies aimed at benefiting the working class. “Zulfikar Ali Bhutto gave Pakistan its first economic policy, with reforms benefiting the common people, not the elites.” Further reflecting on the party’s history, Bhutto spoke of the late Benazir Bhutto’s pivotal role in guiding PPP through challenging times. “Benazir Bhutto’s courage was unmatched; she led the party with strength, even in the face of adversity,” he stated, recalling her leadership during the difficult periods of military rule. He lamented her tragic assassination, which he said was a direct attempt to weaken the PPP, but affirmed that the party remained resilient, revitalised under the leadership of former President Asif Ali Zardari. The PPP chairman expressed pride in his party’s accomplishments, such as the 18th Amendment and the creation of the China-Pakistan Economic Corridor (CPEC), both of which, he said, fulfilled key promises made by Benazir Bhutto. “Under Zardari’s leadership, we passed the 18th Amendment, granted provincial autonomy, and tackled poverty through initiatives like the Benazir Income Support Programme,” Bhutto remarked. Save my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );