Allegations of vote-buying surface amid Malawi’s voter registration process9jili 。

MCLA-129 is a monoclonal antibody commercialized by , with a leading Phase II program in Solid Tumor. According to Globaldata, it is involved in 3 clinical trials, which are ongoing. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for MCLA-129 is expected to reach an annual total of $35 mn by 2040 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. MCLA-129 Overview MCLA-129 is under development for the treatment of solid tumor including non-small cell lung cancer, gastric cancer, esophageal squamous cell cancer (ESCC), gastroesophageal junction (GC/GEJ) adenocarcinoma, Paranasal Sinus And Nasal Cavity Cancer; Oropharyngeal Cancer; Laryngeal Cancer, head and neck cancer and colorectal cancer. It is administered through intravenous drip. The therapeutic candidate is a bi-specific monoclonal antibody that acts by targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET). The drug candidate is being developed based on Multiclonics (biclonics) technology platform. Merus Overview is a clinical-stage oncology company that develops innovative antibody therapeutics. The company utilizes the Multiclonics, Biclonics and Triclonics platforms to develop human bispecific and tri-specific antibodies. Its pipeline products include petosemtamab (MCLA-158), a low-fucose human full-length IgG1 antibody that targets head and neck squamous cell carcinoma (HNSCC); MCLA-129 and MCLA-145 targeting advanced non-small cell lung cancer (NSCLC) and solid tumors; Zenocutuzumab (MCLA-128), antibody-dependent cell-mediated cytotoxicity (ADCC) drug for non-small cell lung cancer and pancreatic cancer; ONO-4685 for refractory T cell lymphoma and psoriasis; and INCA32459 and INCA33890 for advanced malignancies and select advanced solid tumors. The company operates through its subsidiaries in the Netherlands and the US. is headquartered in Utrecht, the Netherlands. The company reported revenues of (US Dollars) US$44 million for the fiscal year ended December 2023 (FY2023), an increase of 5.7% over FY2022. The operating loss of the company was US$156.6 million in FY2023, compared to an operating loss of US$160 million in FY2022. The net loss of the company was US$154.9 million in FY2023, compared to a net loss of US$131.2 million in FY2022. The company reported revenues of US$7.3 million for the second quarter ended June 2024, a decrease of 7.1% over the previous quarter. For a complete picture of MCLA-129’s valuation, This content was updated on 11 March 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .OTTAWA — Prime Minister Justin Trudeau said dealing with incoming president Donald Trump and his thundering on trade will be “a little more challenging” than the last time he was in the White House. Speaking at an event put on by the Halifax Chamber of Commerce, Trudeau said that’s because Trump’s team is coming in with a much clearer set of ideas of what they want to do right away than after his first election win in 2016. Even still, Trudeau said the answer is not to panic and said Canada can rally together to address the tough scenario the nation will face following Trump’s inauguration in January. Trump has threatened 25 per cent tariffs against Canada and Mexico, if the two nations do not beef up their borders to his satisfaction. On the weekend, Trump appeared in an interview with NBC’s “Meet the Press,” where the president-elect said he can’t guarantee the tariffs won’t raise prices for U.S. consumers but that eventually tariffs will “make us rich.” “All I want to do is I want to have a level, fast, but fair playing field,” he said. Trudeau warned that steep tariffs could be “devastating for the Canadian economy” and cause “just horrific losses in all of our communities,” and that Trump’s approach is to introduce “a bit of chaos” to destabilize his negotiating partners. But he also said that Canada exports a range of goods to the U.S., from steel and aluminum to crude oil and agricultural commodities, all of which would get more expensive and mean real hardship for Americans at the same time. “For years, Americans have been paying more for their homes than they should because of unjust tariffs on softwood lumber. Maybe this level of tariffs will actually have them realize that this is something they are doing to themselves,” Trudeau said. “Trump got elected on a commitment to make life better and more affordable for Americans, and I think people south of the border are beginning to wake up to the real reality that tariffs on everything from Canada would make life a lot more expensive.” Experts, including Canada’s former top trade negotiator Steve Verheul, have warned the country needs to be ready to respond if Trump goes through with his tariff threats. The prime minister said his government is still mulling over “the right ways” to respond, referencing Canada’s calculated approach when Trump hit Canada with steel and aluminum tariffs. “It was the fact that we put tariffs on bourbon and Harley-Davidsons and playing cards and Heinz ketchup and cherries and a number of other things that were very carefully targeted because they were politically impactful to the president’s party and colleagues,” he said. That’s how Canada was able to “punch back in a way that was actually felt by Americans,” he added. Trudeau also said the country needs to rally together and work past its political differences. He offered up some rare words of praise for Saskatchewan Premier Scott Moe — a frequent political thorn in his side and “no big fan of mine” — as one of Canada’s strongest voices during that tumultuous time period when NAFTA was under threat. “His voice with governors down south, his making the case for Canadian workers and Canadian trade in a way that complemented the arguments that we were making, did a better job of showing what Canadian unity was and (what) Canada’s negotiating position could be to a United States that has a political system that is incredibly fractured and fractious,” Trudeau said. On Sunday, Conservative Leader Pierre Poilievre said “every single Conservative would tell every single American” that tariffs on Canada would be a bad idea — and also took time to bill Trudeau as a weak leader. One member of his caucus, Conservative MP Jamil Jivani, said he had dinner with incoming vice-president JD Vance and British Conservative Leader Kemi Badenoch over the weekend in Arlington, Va. He said it’s crucial right now to be building “strong relationships with our allies.” — With files from The Associated Press, Kelly Geraldine Malone and Rosa Saba in Toronto

MMA star Conor McGregor found liable for 2018 sexual assaultThe Metropolitan Education District (MetroED) has been awarded a grant of almost $1 million from a state program that helps community colleges expand career technical education and workforce training to prepare students for high-wage employment in industries that meet regional labor market needs. MetroED’s Silicon Valley Career Technical Education (SVCTE) received $989,645 through the K12 Strong Workforce Program. This funding will support SVCTE’s efforts to meet the increasing demand for green technology, providing students with skills needed for sustainable industries. These industries include electric vehicle technology, eco-friendly HVAC systems, fire science with environmental solutions and clean diesel technologies. MetroED provides career technical education for high school and adult students in Santa Clara County. It is overseen by a joint powers agreement that includes the Campbell Union High School District. Its educational partners include Evergreen Community College, Mission College, San Jose City College and West Valley College. The Valley Water Board of Directors on Dec. 10 elected Tony Estremera as the board chair for 2025. Richard P. Santos was elected as vice chair. Estremera has been a member of the Valley Water Board since 1996 and is serving his fifth term as chair. He represents District 6, which encompasses areas of Central and East San Jose, including the Mayfair neighborhood. Santos is beginning his fifth term as vice chair. He represents District 3, which includes Alviso, Sunnyvale, Santa Clara, Milpitas and the Berryessa/Alum Rock area of San Jose.

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Super Bowl Preview?! Breaking down the Buffalo Bills vs. Detroit LionsOn Football analyzes the biggest topics in the NFL from week to week. For more On Football analysis, head here . Saquon Barkley has become the Shohei Ohtani of the NFL. There’s no better home run hitter playing football right now. Barkley had touchdown runs of 72 and 70 yards for the Philadelphia Eagles in a 37-20 victory over the Los Angeles Rams on Sunday night. He now has five runs of 50-plus yards this season and is on pace to break Eric Dickerson’s single-season record of 2,105 yards set in 1984. Barkley’s historic performance against the Rams — his 255 yards set a team record — captivated a national audience and turned him into a fan favorite for the AP NFL MVP award. He’s not the betting favorite, however. Josh Allen has the best odds at plus-150, according to Bet MGM Sportsbook. Two-time MVP Lamar Jackson is next at plus-250 followed by Barkley at plus-400. Running backs have won the award 18 times, including three-time winner Jim Brown, who was the AP’s first NFL MVP in 1957. Quarterbacks have dominated the award, winning it 45 times. Only three players who weren’t QBs or RBs have been MVP. It takes a special season for a non-QB to win it mainly because the offense goes through the signal caller. Quarterbacks handle the ball every offensive snap, run the show and get the credit when things go well and the blame when it doesn’t. Adrian Peterson was the most recent non-QB to win it when he ran for 2,097 yards and 12 touchdowns for the Minnesota Vikings in 2012. Playing for a winning team matters, too. Nine of the past 11 winners played for a No. 1 seed with the other two winners on a No. 2 seed. The Vikings earned the sixth seed when Pederson was MVP. Barkley is a major reason why the Eagles (9-2) are leading the NFC East and only trail Detroit (10-1) by one game for the top spot in the conference. Does he have a realistic chance to win the MVP award? Kicker Mark Moseley was the MVP in the strike-shortened 1982 season when he made 20 of 21 field goals and 16 of 19 extra points in nine games for Washington. If voters once selected a kicker, everyone has a chance, especially a game-changer such as Barkley. Defensive tackle Alan Page was the MVP in 1971 and linebacker Lawrence Taylor won it in 1986. Running back Christian McCaffrey finished third in voting last year and wide receiver Justin Jefferson placed fifth in 2022. The Offensive Player of the Year award and Defensive Player of the Year award recognize the best all-around players on both sides of the ball, allowing voters to recognize non-QBs if they choose. Wide receivers and running backs have won the AP OPOY award seven times over the past 11 seasons. McCaffrey was the 2023 winner. The AP’s new voting format introduced in 2022 also gives non-QBs a better opportunity to get MVP recognition. Voter submit their top five picks for each award, with a weighted point system. Previously, voters made one choice for each award. A nationwide panel of 50 media members who regularly cover the league vote for MVP and seven other awards. The awards are based on regular-season performance. The Chiefs (10-1) and Bills (9-2) already are in position to lock up postseason berths right after Thanksgiving. Kansas City clinches a playoff berth with a win over Las Vegas on Black Friday and a loss by Miami on Thursday night, or a win plus a loss by Denver on Monday night. Buffalo can wrap up a fifth straight AFC East title with a victory over San Francisco on Sunday and a loss by the Dolphins. It’s not a given that the Dallas Cowboys will be looking for a new head coach after this season. Owner Jerry Jones said Tuesday on local radio that Mike McCarthy could end up getting a contract extension. “I don’t think that’s crazy at all. This is a Super Bowl-winning coach. Mike McCarthy has been there and done that. He has great ideas. We got a lot of football left,” Jones said. McCarthy led the Cowboys (4-7) to three straight 12-win seasons, but they went 1-3 in the playoffs and haven’t reached the NFC championship game since winning the Super Bowl 29 years ago. Injuries have contributed to the team’s struggles this season, but Dallas was just 3-5 before Dak Prescott was lost for the rest of the season. The Cowboys upset Washington last week and their next four games are against teams that currently have losing records. If they somehow end up 9-8 or even 8-9, Jones could make a case for keeping McCarthy. AP NFL: https://apnews.com/hub/nfl

NBA's Christmas Day ratings skyrocket, even going up against NFL gamesNEW YORK — Juan Soto put on a New York Mets jersey and cap for the first time Thursday after his record $765 million, 15-year contract was finalized and talked about what made the difference in his decision. “They showed me a lot of love. ... How they're going to make it comfortable for me,” he said. "That's one of the things I was looking for." Soto was introduced at Citi Field a day after his deal was finalized. Speaking in the Piazza 31 Club, he was flanked by Mets owner Steve Cohen, president of baseball operations David Stearns and his agent, Scott Boras. “They always talk about family. They always talk about stick(ing) together,” Soto said. “That's one of the things that opened my eyes.” Security men in gray suits wearing earpieces were off to the side. Soto walked in led by Boras, wearing a dark suit, black turtle neck shirt and gold chain with his No. 22. “I’m excited by the Mets future,” Cohen said. “I think this accelerates our goal of winning championships.” Soto chose the Mets' offer on Sunday, deciding to leave the Yankees after helping them reach the World Series in his only season in the Bronx. SAN FRANCISCO — Willy Adames wasted little time making one thing clear: He wants to play all 162 games for the San Francisco Giants. So when introduced as their new shortstop Thursday, Adames looked to his left and gently put a hand on manager Bob Melvin's right shoulder, smiled and said, “if he lets me.” Melvin might not need much convincing, thrilled to suddenly have stability at a position that lacked continuity this year in his first season as skipper. Adames didn't hesitate to also offer a thought to new boss Buster Posey: He plans to win a few championships with the Giants just like the catcher-turned-executive did here. Surrounded by his parents and other family and friends, Adames was formally introduced and welcomed at Oracle Park after signing a $182 million, seven-year contract — the first big, splashy move made by Posey since he became President of Baseball Operations in late September. “There’s no words to describe my feeling right now to be here in this beautiful city, I’m just so happy to be here,” Adames said. "... This is a dream come true for me. I’m thrilled to be here, I’m so excited. Hopefully we can win a few championships like you did, and that’s one of the main reasons I’m here.” PUERTO PLATA, Dominican Republic — The trial against Tampa Bay Rays shortstop Wander Franco, who has been charged with sexually abusing a minor, sexual and commercial exploitation against a minor, and human trafficking, was postponed on Thursday and scheduled to resume June 2, 2025. Dominican judge Yacaira Veras postponed the hearing at the request of prosecutors because of the absence of several key witnesses in the case. Only three out of 31 witnesses arrived to the hearing on Thursday. Franco’s lawyers asked the court to reconsider the postponement, arguing Franco must report to spring training in mid-February. “There is no case against Wander, for as many witnesses as they present, there is no case now,” Franco's lead lawyer Teodosio Jáquez told The Associated Press after the hearing. The judge replied that Franco is obligated to continue with the trial schedule and his conditional release from detainment. Get local news delivered to your inbox!