NoneWhen the third goal from Brenden Aaronson arrived that guaranteed Leeds would be going top of the Championship, Daniel Farke danced down the touchline and punched the air so much his hair jiggled. When the teams met at Elland Road in August, in the Carabao Cup, Middlesbrough had left with a 3-0 win and Elland Road was filled with jeers. Leeds were losing games and players back then. It has not been easy to get a team defeated in the play-off final a season after relegation to get going again. Farke’s exuberance spoke of his relief. He was still punching the air when he walked to greet his players at full-time. No one was afforded a bigger hug from the boss than Daniel James. He was outstanding, creating the first goal, and scoring the second, with the game level and in the balance in the closing stages, before Aaronson’s clincher.
Copy link Copied Copy link Copied Subscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe. Already a subscriber? Login Amazon is investing an additional $US4 billion ($6.2 billion) in artificial intelligence startup Anthropic, boosting its stake in one of OpenAI’s chief rivals. The new infusion, announced by the companies on Friday (Saturday AEDT), follows a $US4 billion investment in Anthropic completed earlier this year. That deal included provisions that Anthropic use Amazon Web Services data centres for some of its computing needs, as well as AWS-designed AI chips. Anthropic also has close ties with Alphabet’s Google. Bloomberg Copy link Copied Copy link Copied Subscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe. Already a subscriber? Login Introducing your Newsfeed Follow the topics, people and companies that matter to you. Latest In Technology Fetching latest articles Most Viewed In TechnologyCJ 4DPLEX and Cinema West Sign Multi-Theater Deal To Launch 270-Degree Panoramic ScreenX and Multisensory 4DX Auditoriums Across California
Kai Trump shows Elon Musk awkwardly tutoring Trump in rocket scienceBitcoin catapulted above $100,000 for the first time on Thursday, a milestone hailed even by sceptics as a coming-of-age for digital assets as investors bet on a friendly U.S. administration to cement the place of cryptocurrencies in financial markets. Once it broke $100,000 in Thursday's Asian morning, boosted by U.S. President-elect Trump's nomination of pro-crypto Paul Atkins to run the Securities and Exchange Commission, it was soon at an all-time high of $103,649. It last fetched $98,803, up 0.95% on the day BTC=. The total value of the cryptocurrency market has almost doubled over the year so far to hit a record over $3.8 trillion, according to data provider CoinGecko. By comparison, Apple alone is worth about $3.7 trillion. Bitcoin's march from the libertarian fringe to Wall Street has minted millionaires, a new asset class and popularised the concept of "decentralized finance" in a volatile and often controversial period since its creation 16 years ago. Bitcoin has more than doubled in value this year and is up more than 50% in the four weeks since Donald Trump's sweeping election victory, which also saw a slew of pro-crypto lawmakers being elected to Congress. "CONGRATULATIONS BITCOINERS!!! $100,000!!! YOU’RE WELCOME!!! Together, we will Make America Great Again!" Trump said on Truth Social, his social media network, on Thursday. "We're witnessing a paradigm shift," said Mike Novogratz, founder and CEO of U.S. crypto firm Galaxy Digital. "Bitcoin and the entire digital asset ecosystem are on the brink of entering the financial mainstream - this momentum is fuelled by institutional adoption, advancements in tokenisation and payments, and a clearer regulatory path." Trump - who once labelled crypto a scam - embraced digital assets during his campaign, promising to make the United States the "crypto capital of the planet" and to accumulate a national stockpile of bitcoin. "We were trading basically sideways for about seven months, then immediately after Nov. 5, U.S. investors resumed buying hand-over-fist," said Joe McCann, CEO and founder of Asymmetric, a Miami digital assets hedge fund. Bitcoin's proponents cheered Trump's nomination of Atkins to the SEC. A former SEC commissioner, Atkins has been involved in crypto policy as co-chair of the Token Alliance, which works to "develop best practices for digital asset issuances and trading platforms," and the Chamber of Digital Commerce. "Atkins will offer a new perspective, anchored by a deep understanding of the digital asset ecosystem," said Blockchain Association CEO Kristin Smith. "We look forward to working with him ... and ushering in – together – a new wave of American crypto innovation." A slew of crypto companies including Ripple, Kraken and Circle are also jostling for a seat on Trump's promised crypto advisory council. Part of the landscape Bitcoin has proven a survivor through precipitous downturns. Its move into six-figure territory is a remarkable comeback from a dip below $16,000 in 2022 when the industry was reeling from the collapse of the FTX exchange. Founder Sam Bankman-Fried was subsequently jailed. Analysts say the growing embrace of bitcoin by big investors this year has been a driving force behind the record-breaking rally. U.S.-listed bitcoin exchange-traded funds were approved in January and have been a conduit for large-scale buying, with more than $4 billion streaming into these funds since the election. "Roughly 3% of the total supply of bitcoins that will ever exist have been purchased in 2024 by institutional money," said Geoff Kendrick, global head of digital assets research at Standard Chartered. "Digital assets, as an asset class, is becoming normalised," he said. It is already becoming increasingly financialised, with the launch of bitcoin futures BTCc1 in 2017 and a strong debut for options on BlackRock's ETF IBIT.O in November. Crypto-related stocks have soared along with the bitcoin price, with shares in bitcoin miner MARA Holdings MARA.O and exchange operator Coinbase COIN.O each up around 65% in November. Software firm Microstrategy MSTO.O, which has repeatedly raised funds to buy bitcoin and held an aggregate of about 402,100 bitcoins as of Dec. 1, has gained around 540% this year. Trump himself unveiled a new crypto business, World Liberty Financial, in September, although details have been scarce and billionaire Elon Musk, a major Trump ally, is also a proponent of cryptocurrencies. Some say the asset remains a speculative or investment vehicle and not an instrument for payments. On Wednesday, Federal Reserve Chair Jerome Powell likened bitcoin to gold, “only it's virtual, it's digital." "People are not using it as a form of payment, or as a store of value. It's highly volatile, it’s not a competitor for the dollar." While earlier big bitcoin rallies have been followed by significant pullbacks, its wider adoption now may help tamp down volatility, analysts said. "That is not to say that there will not be 30-50% drawdowns over time, but my base case is that the nature of the drawdowns will be less severe than what we saw in the last bear market," Sean Farrell, head of digital asset strategy at Fundstrat Global Advisors, said. "Passive flows into ETFs, a liquid options market, corporate treasury adoption, and nation state adoption will likely play a large role in dampening volatility," Farrell said. 'Who can prohibit it' Cryptocurrencies have been criticised for their massive energy consumption and use in crime around the world, and the underlying technology is far from delivering a revolution in the way money moves around the globe. The U.S. and Britain announced on Wednesday they had disrupted what they described as a global money laundering ring which used cryptocurrency to help rich Russians to evade sanctions and launder cash for drug traffickers. Although calculations vary, the Cambridge University Centre for Alternative Finance estimates bitcoin uses around the same amount of electricity each year as Poland or South Africa. Still, as Russian President Vladimir Putin pointed out at an investment conference on Wednesday: "Who can prohibit it? No one." And its longevity is perhaps testament to a degree of resilience. "As time goes by it's proving itself as part of the financial landscape," said Shane Oliver, chief economist and head of investment strategy at AMP in Sydney. "I find it very hard to value it ... it's anyone's guess. But it does have a momentum aspect to it and at the moment the momentum is up." — Reuters
Watch: Climate Minister Simon Watts explains new emissions planAfter months of speculation and anticipation, Marvel fans around the world were ecstatic to hear the news that Chris Evans will be returning as Captain America for the highly anticipated Avengers 5. What's even more exciting is that Evans will be reuniting with his longtime co-star, Robert Downey Jr., who will be reprising his role as Iron Man. The dynamic duo, who captured audiences' hearts with their impeccable on-screen chemistry, are set to once again don their iconic suits and join forces to save the world.In a moment of spontaneity, John decided to embrace the unexpected twist of fate and welcomed the teddy bear into his home. Naming him "Dee Dee" after the famous cartoon character, John found himself enjoying the quirky presence of his new, not-so-utilitarian companion.
Induction Cookware Market to Grow at 6.4% CAGR, Reaching $2.64 Billion by 2030 from $1.61 Billion in 2022 11-27-2024 08:33 PM CET | Business, Economy, Finances, Banking & Insurance Press release from: Data Bridge Market Research (DBMR) / PR Agency: Data Bridge Market Research (DBMR) The Induction Cookware Market sector is undergoing significant transformation, with substantial growth and technological advancements expected by 2031. According to a new in-depth market research report, the sector is poised for expansion, driven by various factors such as market size, share, and emerging trends. This comprehensive report provides key insights into the Induction Cookware market, exploring critical market segmentation and definitions. It highlights the essential components driving growth, offering a clear picture of the industry's trajectory. Utilizing SWOT and PESTEL analyses, the report evaluates the market's strengths, weaknesses, opportunities, and threats, while also considering political, economic, social, technological, environmental, and legal factors that impact the market landscape. The study offers valuable insights into the competitive landscape, highlighting recent developments and geographical distribution across key regions. Expert competitor analysis provides a detailed understanding of market dynamics, offering strategic guidance for businesses and investors. With robust analysis and future projections, this report serves as a vital resource for stakeholders looking to capitalize on emerging opportunities and navigate challenges in the Induction Cookware market. What is the projected market size & growth rate of the Induction Cookware Market? Market Analysis and Size The market is being stimulated by an increase in dining establishments and other eating places, as well as residential and non-residential development projects. Since there is still a demand for fast food restaurants, the industry's increased performance and profitability create enough market opportunities. Rising gas cooktop fuel costs as well as the growing acceptance of modular kitchens due to their advantages in terms of comfort and safety are driving the market for household induction cooktops. The growth of home induction cooktop sales is anticipated to be influenced by the adoption of more high-tech and technologically advanced products due to the development of e-commerce websites for kitchen appliances. Data Bridge Market Research analyses that the induction cookware market, valued at USD 1.61 billion in 2022, will reach USD 2.64 billion by 2030, growing at a CAGR of 6.4% during the forecast period of 2023 to 2030. In addition to the market insights such as market value, growth rate, market segments, geographical coverage, market players, and market scenario, the market report curated by the Data Bridge Market Research team includes in-depth expert analysis, import/export analysis, pricing analysis, production consumption analysis, and consumer behavior. Browse Detailed TOC, Tables and Figures with Charts which is spread across 350 Pages that provides exclusive data, information, vital statistics, trends, and competitive landscape details in this niche sector. This research report is the result of an extensive primary and secondary research effort into the Induction Cookware market. It provides a thorough overview of the market's current and future objectives, along with a competitive analysis of the industry, broken down by application, type and regional trends. It also provides a dashboard overview of the past and present performance of leading companies. A variety of methodologies and analyses are used in the research to ensure accurate and comprehensive information about the Induction Cookware Market. Get a Sample PDF of Report - https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-induction-cookware-market Which are the driving factors of the Induction Cookware market? The driving factors of the Induction Cookware market include technological advancements that enhance product efficiency and user experience, increasing consumer demand driven by changing lifestyle preferences, and favorable government regulations and policies that support market growth. Additionally, rising investment in research and development and the expanding application scope of Induction Cookware across various industries further propel market expansion. Induction Cookware Market - Competitive and Segmentation Analysis: Global Induction Cookware Market, By Product (Built-In, Free-Standing, Portable), Instrument Type (Touch Screen, Touchtone), Type (Pan, Stockpot, Cooker, Dutch Oven, Others, Application (Household, Commercial, Restaurants), Distribution Channel (Supermarkets, Hypermarkets, E-Commerce, Specialty Stores, Others) - Industry Trends and Forecast to 2031. How do you determine the list of the key players included in the report? With the aim of clearly revealing the competitive situation of the industry, we concretely analyze not only the leading enterprises that have a voice on a global scale, but also the regional small and medium-sized companies that play key roles and have plenty of potential growth. Which are the top companies operating in the Induction Cookware market? Some of the major players operating in the induction cookware market are: Whirlpool. (U.S.) LG Electronics (South Korea) Electrolux (Sweden) present Magento, Inc. (India) Smeg S.p.A (Italy) Koninklijke Philips N.V. (Netherlands) Robert Bosch GmbH (Germany) Panasonic Holdings Corporation (Japan) Sub Zero Wolf (U.S.) Miele & Cie. KG (Germany) TTK Prestige Ltd. (U.S.) Cuisinart (U.S.) All-Clad (U.S.) GreenPan (U.S.) Anolon (U.S.) SCANPAN (Denmark) KitchenAid (U.S.) Le Creuset (France) Sunbeam Products, Inc. (U.S.) Short Description About Induction Cookware Market: The Global Induction Cookware market is anticipated to rise at a considerable rate during the forecast period, between 2024 and 2031. In 2023, the market is growing at a steady rate and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon. North America, especially The United States, will still play an important role which can not be ignored. Any changes from United States might affect the development trend of Induction Cookware. The market in North America is expected to grow considerably during the forecast period. The high adoption of advanced technology and the presence of large players in this region are likely to create ample growth opportunities for the market. Europe also play important roles in global market, with a magnificent growth in CAGR During the Forecast period 2024-2031. Induction Cookware Market size is projected to reach Multimillion USD by 2031, In comparison to 2024, at unexpected CAGR during 2024-2031. Despite the presence of intense competition, due to the global recovery trend is clear, investors are still optimistic about this area, and it will still be more new investments entering the field in the future. This report focuses on the Induction Cookware in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application. Get a Sample Copy of the Induction Cookware Report 2024 What are your main data sources? Both Primary and Secondary data sources are being used while compiling the report. Primary sources include extensive interviews of key opinion leaders and industry experts (such as experienced front-line staff, directors, CEOs, and marketing executives), downstream distributors, as well as end-users. Secondary sources include the research of the annual and financial reports of the top companies, public files, new journals, etc. We also cooperate with some third-party databases. Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historical data and forecast (2024-2031) of the following regions are covered in Chapters What are the key regions in the global Induction Cookware market? North America (United States, Canada and Mexico) Europe (Germany, UK, France, Italy, Russia and Turkey etc.) Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam) South America (Brazil, Argentina, Columbia etc.) Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa) This Induction Cookware Market Research/Analysis Report Contains Answers to your following Questions What are the global trends in the Induction Cookware market? Would the market witness an increase or decline in the demand in the coming years? What is the estimated demand for different types of products in Induction Cookware? What are the upcoming industry applications and trends for Induction Cookware market? What Are Projections of Global Induction Cookware Industry Considering Capacity, Production and Production Value? What Will Be the Estimation of Cost and Profit? What Will Be Market Share, Supply and Consumption? What about Import and Export? Where will the strategic developments take the industry in the mid to long-term? What are the factors contributing to the final price of Induction Cookware? What are the raw materials used for Induction Cookware manufacturing? How big is the opportunity for the Induction Cookware market? How will the increasing adoption of Induction Cookware for mining impact the growth rate of the overall market? How much is the global Induction Cookware market worth? What was the value of the market In 2020? Who are the major players operating in the Induction Cookware market? Which companies are the front runners? Which are the recent industry trends that can be implemented to generate additional revenue streams? What Should Be Entry Strategies, Countermeasures to Economic Impact, and Marketing Channels for Induction Cookware Industry? Customization of the Report Can I modify the scope of the report and customize it to suit my requirements? Yes. Customized requirements of multi-dimensional, deep-level and high-quality can help our customers precisely grasp market opportunities, effortlessly confront market challenges, properly formulate market strategies and act promptly, thus to win them sufficient time and space for market competition. Detailed TOC of Global Induction Cookware Market Insights and Forecast to 2031 Introduction Market Segmentation Executive Summary Premium Insights Market Overview Induction Cookware Market By Type Induction Cookware Market By Function Induction Cookware Market By Material Induction Cookware Market By End User Induction Cookware Market By Region Induction Cookware Market: Company Landscape SWOT Analysis Company Profiles Continued... https://newstrendshubs.blogspot.com/2024/11/the-deodorants-market-and-its-role-in.html https://newstrendshubs.blogspot.com/2024/11/plate-and-frame-heat-exchangers-market.html https://newstrendshubs.blogspot.com/2024/11/business-intelligence-market-trends.html Data Bridge Market Research: Today's trends are a great way to predict future events! Data Bridge Market Research is a market research and consulting company that stands out for its innovative and distinctive approach, as well as its unmatched resilience and integrated methods. We are dedicated to identifying the best market opportunities, and providing insightful information that will help your business thrive in the marketplace. Data Bridge offers tailored solutions to complex business challenges. This facilitates a smooth decision-making process. Data Bridge was founded in Pune in 2015. It is the product of deep wisdom and experience. Contact Us: Data Bridge Market Research US: +1 614 591 3140 UK: +44 845 154 9652 APAC: +653 1251 975 Email:- corporatesales@databridgemarketresearch.com This release was published on openPR.Moreover, the presence of external actors further complicates the situation. Foreign governments, regional powers, and non-state actors have all been involved in supporting different factions within the anti-government camp, often with conflicting agendas. This external interference can exacerbate existing rivalries, fuel mistrust, and create additional pressure points that could trigger internal conflict.
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Sidney Town Crier retiring after 26 years, celebration plannedGeeMee achieved major partnerships at Mobidictum Conference 2024-Boosting Growth with Ad Tech solutions 11-27-2024 07:52 PM CET | Associations & Organizations Press release from: Getnews / PR Agency: Queqi Culture Media GeeMee took part in the Mobidictum Conference 2024 in Istanbul, showcasing its innovative solutions and the latest advancements in mobile advertising. The company shared its expertise in monetization strategies and provided valuable industry insights, offering publishers and developers practical guidance for achieving sustainable growth at this major gaming industry conference. Building a Strong Presence: Existing Partnerships and New Opportunities GeeMee is empowering app developers across more than 20 countries, forging strong partnerships with exceptional publishers spanning entertainment, tools, video, etc, like Zee in Entertainment and other publishers. Building on this success, GeeMee is actively extending its proven expertise and innovative solutions to the gaming industry. Participation in the Mobidictum Conference 2024 further solidified GeeMee's role as a transformative force in mobile advertising, providing an opportunity to connect with pioneers in the global gaming sector and showcase the advanced potential of its technology in delivering immersive and impactful ad experiences. GeeMee also established strong relationships with new potential partners, including Yamy Studio, Leke Games, Udo Games, Joinco Games, and Unico Studio. These conversations underscored mutual respect and collaboration, with both sides showing alignment with the vision for the future of mobile advertising and opportunities to work together. The Mobidictum Conference in Istanbul served as a vital platform for industry interaction, allowing GeeMee to connect with publishers, developers, and leaders to share insights on evolving trends in mobile advertising. Image: https://www.getnews.info/uploads/3d378c8dd0c8e09c757d319c6834e229.jpg The Industry Landscape: Challenges and New Developments The mobile game industry is navigating a pivotal moment, as developers around the world tackle both challenges and emerging opportunities. In-app advertising has become a cornerstone of monetization, particularly in casual games, where it creates new avenues for engaging both paying and non-paying players. As mobile advertising evolves, developers are placing greater emphasis on improving user engagement. Advancements in AI and machine learning are transforming ad delivery, enabling personalized and meaningful experiences for users. Within this dynamic environment, GeeMee's participation as a gold sponsor at the Mobidictum Conference 2024 highlighted its innovative contributions to the industry. Max Martinez, GeeMee's Head of Strategic Partnerships, shared how its AI-driven technology enhances in-app ad engagement, creating ad experiences that resonate deeply with individual users. GeeMee's solutions are designed to bridge the needs of advertisers, publishers, developers, and users, ensuring that in-app advertising integrates seamlessly into the app experience without compromising quality. By harnessing AI-driven technology, GeeMee enables resource-constrained developers to access advanced tools that empower them to compete effectively in a market often dominated by larger players. These innovations ensure that developers can deliver personalized, impactful ad experiences while maintaining a strong focus on user satisfaction. The Significance and Future Outlook GeeMee's presence at the Mobidictum Conference marked a milestone in its journey within the global gaming industry. As the company broadens its global partnerships and introduces its solutions to new markets, its commitment to advancing mobile in-app advertising remains steadfast. Looking ahead, GeeMee is focused on continuously refining its offerings to align with the evolving needs of developers and users, driving innovation in mobile advertising while enhancing the overall quality of app engagements. Media Contact Company Name: GeeMee Contact Person: Renie Whitney Email: Send Email [ http://www.universalpressrelease.com/?pr=geemee-achieved-major-partnerships-at-mobidictum-conference-2024boosting-growth-with-ad-tech-solutions ] Country: United States Website: http://www.geemee.ai This release was published on openPR.
French President Emmanuel Macron vowed Thursday to stay in office until the end of his term, due in 2027, and announced that he will name a new prime minister within days following the resignation of ousted Prime Minister Michel Barnier. Macron came out fighting a day after a historic no-confidence vote at the National Assembly left France without a functioning government. He laid blame at the door of his opponents on the far right for bringing down the Barnier's government. He said they chose “Not to do but to undo.” “They chose disorder,” he said. The president said the far right and the far left had united in what he called “an anti-Republican front” and stressed: “I won’t shoulder other people’s irresponsibility.” He said he’d name a new prime minister within days but gave no hints who that might be. Earlier in teh day, Macron “took note” of Barnier's resignation, the Elysee presidential palace said in a statement. Barnier and other ministers will be “in charge of current affairs until the appointment of a new government,” the statement said. The no-confidence motion passed by 331 votes in the National Assembly, forcing Barnier to step down after just three months in office—the shortest tenure of any prime minister in modern French history. Macron faces the critical task of naming a replacement capable of leading a minority government in a parliament where no party holds a majority. Yaël Braun-Pivet, president of the National Assembly and a member of Macron’s party, urged the president to move quickly. “I recommend he decide rapidly on a new prime minister,” Braun-Pivet said Thursday on France Inter radio. “There must not be any political hesitation. We need a leader who can speak to everyone and work to pass a new budget bill.” The process may prove challenging. Macron’s administration has yet to confirm any names, though French media have reported a shortlist of centrist candidates who might appeal to both sides of the political spectrum. Macron took more than two months to appoint Barnier after his party’s defeat in June’s legislative elections, raising concerns about potential delays this time. The no-confidence vote has galvanized opposition leaders, with some explicitly calling for Macron’s resignation. “I believe that stability requires the departure of the President of the Republic,” said Manuel Bompard, leader of the far-left France Unbowed party, on BFM TV Wednesday night. Far-right National Rally leader Marine Le Pen, whose party holds the most seats in the Assembly, stopped short of calling for Macron’s resignation but warned that “the pressure on the President of the Republic will get stronger and stronger.” Macron, however, has dismissed such calls and ruled out new legislative elections. The French constitution does not call for a president to resign after his government was ousted by the National Assembly. “I was elected to serve until 2027, and I will fulfill that mandate,” he told reporters earlier this week. The constitution also says that new legislative elections cannot be held until at least July, creating a potential stalemate for policymakers. The political instability has heightened concerns about France’s economy, particularly its debt, which could rise to 7% of GDP next year without significant reforms. Analysts say that Barnier's government downfall could push up French interest rates, digging the debt even further. Rating agency Moody’s warned late Wednesday that the government’s fall “reduces the likelihood of consolidating public finances” and worsens the political gridlock. Macron’s speech, scheduled for 8 p.m. local time, is expected to address these economic challenges while setting a course for the future government. A planned protest by teachers against budget cuts in education took on a new tone Thursday, as demonstrators in Paris linked their demands to the political crisis. “Macron quit!” read a sign held by Dylan Quenon, a 28-year-old teacher at a middle school in Aubervilliers, just north of Paris. Quenon said Macron bears responsibility for what he described as the dismantling of public services like schools. “The only way for this to change is to have him out of office,” he said. Protesters expressed little hope that Macron’s next appointee would reverse course. “I’m glad this government is falling, but it could possibly lead to something even worse,” said Élise De La Gorce, a 33-year-old teacher in Stains, north of Paris.Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.
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