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The Indianapolis Colts seem to be allergic to making the playoffs. With their 45-33 loss to the New York Giants on Sunday, they were officially eliminated from playoff contention for the fourth season in a row. In three of those seasons the Colts have suffered devastating, embarrassing losses in must-win games. It has been such a bad run that Sunday's loss to a previously 2-13 Giants team might not even be the worst of them all. A quick rundown of the recent history for the Colts in these must-win games: -- In 2021 they entered Week 18 of the season simply needing to beat the 2-14 Jacksonville Jaguars to clinch a playoff berth. They ended up losing 26-11 (after falling behind 26-3) and missed the playoffs. -- In 2023 they entered Week 18 needing a win over the Houston Texans to make the playoffs and win the AFC South. They lost when running back Tyler Goodson dropped a wide open pass on a fourth-and-one that could have kept a potential game-winning drive going. Then there was Sunday against the Giants. The Colts still needed some help to get in the playoffs even with a win this time around, but a win was an absolute must to keep their chances alive. They not only failed to get it, they were humiliated. The 2-13 Giants entered the game without having won a single game at home all season. They had lost 10 games in a row. They had not scored more than 22 points in any of those games, and only once scored more than 20 points. They were starting Drew Lock after he entered the season as their third-string quarterback. You hate to say that any game in the NFL should be an assumed win, but this should have been as close to one as you could get for the Colts. Yes, the Colts were also playing with a backup quarterback, as Joe Flacco started in place of the injured Anthony Richardson, but there is probably an argument to be made that Flacco is a better quarterback at this stage of both player's careers. The Colts also scored 33 points. Unfortunately for them, they allowed 45 points with Lock accounting for five touchdowns (four passing and one rushing) and posting a 155.3 passer rating in what might have been the best game of his career. In terms of worst losses, the 2021 game in Jacksonville is still the most humiliating because that was a win-and-in game. The 2023 game in Houston was against a good team that was probably a coin-flip going in. The loss hurt, especially with the crucial drop, but there was no shame in the defeat. The most recent letdown probably sandwiches in the middle of the three. Combined with the game in Denver two weeks ago that swung when running back Jonathan Taylor prematurely dropped the ball at the goal line celebrating a sure touchdown, the Colts are going to have a long offseason of "what ifs" ahead of them.

Loo-less town's battle illustrates national problemDel. Dana Jones, who has represented the greater Annapolis area for more than four years, intends to run for the open Senate seat in January.

Ravens vs. Chargers live updates: LB Roquan Smith inactive for ‘Monday Night Football’WOBURN, Mass., Nov. 21, 2024 (GLOBE NEWSWIRE) -- Replimune Group, Inc. REPL , a clinical stage biotechnology company pioneering the development of novel oncolytic immunotherapies, today announced that it has submitted a biologics license application (BLA) to the FDA for RP1 (vusolimogene oderparepvec) in combination with nivolumab for the treatment of adult patients with advanced melanoma who have previously received an anti-PD1 containing regimen. The submission was made under the Accelerated Approval pathway. The Company also announced that the FDA has granted Breakthrough Therapy designation to RP1 in combination with nivolumab in the same setting. Breakthrough Therapy designation is intended to expedite the development and review of therapies for serious diseases when preliminary clinical evidence indicates that the therapy may provide substantial improvement over existing available therapies on one or more clinically significant endpoints. This Breakthrough Therapy designation is based on the safety and clinical activity observed in the anti-PD1 failed melanoma cohort of the IGNYTE clinical trial. "Today is an important milestone for Replimune and for the melanoma community as we are one step closer to having another potential treatment available for patients who have limited options after progressing on anti-PD1 containing regimens," said Sushil Patel, Ph.D., CEO of Replimune. The confirmatory Phase 3 IGNYTE-3 trial of RP1 in combination with nivolumab in advanced melanoma patients who have progressed on anti-PD1 and anti-CTLA-4 therapy, or who are not candidates for anti-CTLA-4 treatment is currently enrolling patients. For more information, visit https://replimune.com/clinical-trials/ignyte-3/ . About RP1 RP1 (vusolimogene oderparepvec) is Replimune's lead product candidate and is based on a proprietary strain of herpes simplex virus engineered and genetically armed with a fusogenic protein (GALV-GP R-) and GM-CSF, intended to maximize tumor killing potency, the immunogenicity of tumor cell death, and the activation of a systemic anti-tumor immune response. About Replimune Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of novel oncolytic immunotherapies. Replimune's proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit www.replimune.com . Forward Looking Statements This press release contains forward looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding our belief regarding the effect that the breakthrough designation will have on the timing and development of RP1 and other statements identified by words such as "could," "expects," "intends," "may," "plans," "potential," "should," "will," "would," or similar expressions and the negatives of those terms. Forward-looking statements are not promises or guarantees of future performance, and are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in such forward-looking statements. These factors include risks related to our limited operating history, our ability to generate positive clinical trial results for our product candidates, the costs and timing of operating our in-house manufacturing facility, the timing and scope of regulatory approvals, the availability of combination therapies needed to conduct our clinical trials, changes in laws and regulations to which we are subject, competitive pressures, our ability to identify additional product candidates, political and global macro factors including the impact of the coronavirus as a global pandemic and related public health issues and the Russian-Ukrainian and Israel-Hamas political and military conflicts, and other risks as may be detailed from time to time in our Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q and other reports we file with the Securities and Exchange Commission. Our actual results could differ materially from the results described in or implied by such forward-looking statements. Forward-looking statements speak only as of the date hereof, and, except as required by law, we undertake no obligation to update or revise these forward-looking statements. Investor Inquiries Chris Brinzey ICR Healthcare 339.970.2843 chris.brinzey@westwicke.com Media Inquiries Arleen Goldenberg Replimune 917.548.1582 media@replimune.com © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.New Zealand’s dairy sector faces an uncertain future due to several challenges, including water pollution , high emissions , animal welfare concerns and market volatility . All of these issues are building tensions and changing public perceptions of dairy farming . In my new research , I argue the time has come for the dairy sector to adopt a “just transition” framework to achieve a fair and more sustainable food future and to navigate the disruptions from alternative protein industries. The concept of a just transition is typically applied to the energy sector in shifting from fossil fuels to renewable energy sources. But a growing body of research and advocacy is calling for the same principles to be applied to food systems, especially for shifting away from intensive animal agriculture. Aotearoa New Zealand’s dairy sector is an exemplary case study for examining the possibilities of a just transition because it is so interconnected in the global production and trade of dairy, with 95% of domestic milk production exported as whole-milk powder to more than 130 countries. Environmental and economic challenges New Zealand’s dairy sector faces significant threats. This includes environmental challenges such as alarming levels of nitrate pollution in waterways caused by intensive agriculture. The sector is also a major source of emissions of biogenic methane from the burps of almost six million cows in the national dairy herd. Debates about how to account for these emissions have gone on for many years in New Zealand. But last month, the coalition government passed legislation to keep agriculture out of the Emissions Trading Scheme . This means livestock farmers, agricultural processors, fertiliser importers and manufacturers won’t have to pay for on-farm emissions. Instead, the government intends to implement a pricing system outside the Emissions Trading Scheme by 2030. To meet emissions targets, it relies on the development of technologies such as methane inhibitors. In addition to environmental challenges, global growth and domestic initiatives in the development of alternative dairy products are changing the future of milk production and consumption. New Zealand dairy giant Fonterra is pursuing the growth of alternative dairy with significant investments in a partnership with Dutch multinational corporation Royal-DSM. This supports precision fermentation start-up Vivici, which already has market-ready products such as whey protein powder and protein water . Fonterra’s annual report states it anticipates a rise in customer preference towards dairy alternatives (plant-based or precision-fermentation dairy) due to climate-related concerns. The company says these shifting preferences could pose significant business risks for future dairy production if sustainability expectations cannot be met. Pathways to a just transition for dairy What happens when one the pillars of the economy becomes a major contributor to environmental degradation and undermines its own sustainability? Nitrate pollution and methane emissions threaten the quality of the land and waterways the dairy sector depends on. In my recent study which draws on interviews with people across New Zealand’s dairy sector, three key transition pathways are identified, which address future challenges and opportunities. Deintensification : reducing the number of dairy cows per farm. Diversification : introducing a broader range of farming practices, landuse options and market opportunities. Dairy alternatives : government and industry support to help farmers participate in emerging plant-based and precision-fermentation industries. While the pathways are not mutually exclusive, they highlight the socioeconomic and environmental implications of rural change which require active participation and engagement between the farming community and policy makers. The Ministry of Business, Innovation and Employment recently published a guide to just transitions . It maps out general principles such as social justice and job security. But the guide is light on advice for agricultural transitions. My work puts forward recommendations to shape future policy for a more just and sustainable dairy future. This includes issues such as navigating intensification pressures , supporting the development of alternative proteins and fundamentally supporting farmer agency in the transition process. For the dairy transition to be fair and sustainable, we need buy-in from leadership and support from government, the dairy sector and the emerging alternative dairy industry to help primary producers and rural communities. This needs to be specific to different regions and farming methods. The future of New Zealand’s dairy industry depends on its ability to adapt. Climate adaptation demands balancing social license, sustainable practices and disruptions from novel protein technologies.I'm A Celebrity's Coleen Rooney rumbles 'fake' stars as lies exposed on ITV show

Confluent CFO Sivaram Rohan sells $641,216 in stock

CMG Deadline Alert: CMG Investors with Losses in Excess of $100K Have Opportunity to Lead Chipotle Mexican Grill, Inc. Securities Fraud Lawsuit Filed by The Rosen Law FirmChildren of the wealthy and connected get special admissions consideration at some elite U.S. universities, according to new filings in a class-action lawsuit originally brought against 17 schools. Georgetown’s then-president, for example, listed a prospective student on his “president’s list” after meeting her and her wealthy father at an Idaho conference known as “summer camp for billionaires,” according to Tuesday court filings in the price-fixing lawsuit filed in Chicago federal court in 2022. Although it’s always been assumed that such favoritism exists, the filings offer a rare peek at the often secret deliberations of university heads and admissions officials. They show how schools admit otherwise unqualified wealthy children because their parents have connections and could possibly donate large sums down the line, raising questions about fairness. Stuart Schmill, the dean of admissions at the Massachusetts Institute of Technology, wrote in a 2018 email that the university admitted four out of six applicants recommended by then-board chairman Robert Millard, including two who “we would really not have otherwise admitted.” The two others were not admitted because they were “not in the ball park, or the push from him was not as strong.” In the email, Schmill said Millard was careful to play down his influence on admissions decisions, but he said the chair also sent notes on all six students and later met with Schmill to share insight “into who he thought was more of a priority.” The filings are the latest salvo in a lawsuit that claims that 17 of the nation’s most prestigious colleges colluded to reduce the competition for prospective students and drive down the amount of financial aid they would offer, all while giving special preference to the children of wealthy donors. “That illegal collusion resulted in the defendants providing far less aid to students than would have been provided in a free market,” said Robert Gilbert, an attorney for the plaintiffs. Since the lawsuit was filed, 10 of the schools have reached settlements to pay out a total of $284 million, including payments of up to $2,000 to current or former students whose financial aid might have been shortchanged over a period of more than two decades. They are Brown, the University of Chicago, Columbia, Dartmouth, Duke, Emory, Northwestern, Rice, Vanderbilt and Yale. Johns Hopkins is working on a settlement and the six schools still fighting the lawsuit are the California Institute of Technology, Cornell, Georgetown, MIT, Notre Dame and the University of Pennsylvania. MIT called the lawsuit and the claims about admissions favoritism baseless. “MIT has no history of wealth favoritism in its admissions; quite the opposite,” university spokesperson Kimberly Allen said. “After years of discovery in which millions of documents were produced that provide an overwhelming record of independence in our admissions process, plaintiffs could cite just a single instance in which the recommendation of a board member helped sway the decisions for two undergraduate applicants.” In a statement, Penn also said the case is meritless that the evidence shows that it doesn’t favor students whose families have donated or pledged money to the Ivy League school. “Plaintiffs’ whole case is an attempt to embarrass the University about its purported admission practices on issues totally unrelated to this case,” the school said. Notre Dame officials also called the case baseless. “We are confident that every student admitted to Notre Dame is fully qualified and ready to succeed,” a university spokesperson said in a statement. The South Bend, Indiana, school, though, did apparently admit wealthy students with subpar academic backgrounds. According to the new court filings, Don Bishop, who was then associate vice president for enrollment at Notre Dame, bluntly wrote about the “special interest” admits in a 2012 email, saying that year’s crop had poorer academic records than the previous year’s. The 2012 group included 38 applicants who were given a “very low” academic rating, Bishop wrote. He said those students represented “massive allowances to the power of the family connections and funding history,” adding that “we allowed their high gifting or potential gifting to influence our choices more this year than last year.” The final line of his email: “Sure hope the wealthy next year raise a few more smart kids!” Some of the examples pointed to in this week’s court filings showed that just being able to pay full tuition would give students an advantage. During a deposition, a former Vanderbilt admissions director said that in some cases, a student would get an edge on the waitlist if they didn’t need financial aid. The 17 schools were part of a decades-old group that got permission from Congress to come up with a shared approach to awarding financial aid. Such an arrangement might otherwise violate antitrust laws, but Congress allowed it as long as the colleges all had need-blind admissions policies, meaning they wouldn’t consider a student’s financial situation when deciding who gets in. The lawsuit argues that many colleges claimed to be need-blind but routinely favored the children of alumni and donors. In doing so, the suit says, the colleges violated the Congressional exemption and tainted the entire organization. The group dissolved in recent years when the provision allowing the collaboration expired. ___ The Associated Press’ education coverage receives financial support from multiple private foundations. AP is solely responsible for all content. Find AP’s standards for working with philanthropies, a list of supporters and funded coverage areas at AP.org. Children of the wealthy and connected get special admissions consideration Jay-Z’s lawyers asked a judge Wednesday to speedily extract the (AP) — McKinsey & Company consulting firm has agreed to NASA’s two stuck astronauts just got their space mission extended

NoneMinisters said an extra £15 million will be made available for supply chain businesses and workers affected by changes at Tata’s Port Talbot site in south Wales. Welsh Secretary Jo Stevens said the move means a fund to support businesses across Wales heavily reliant on Tata steel will be increased to £30 million. She also announced that more businesses will be able to apply for the funds, and the value of individual grants is increasing to up to £250,000 for businesses to invest in equipment, property, technology. The Government said there has been “significant demand” on the existing funding, with almost 40 businesses employing 2,000 people having begun the application process. Grants worth millions of pounds are expected to be released in the new year. The increase in funding is in anticipation of more people leaving Tata in early 2025 through the company’s voluntary redundancy scheme. Ms Stevens said: “This Government is acting decisively to support workers and businesses in Port Talbot. “We are doubling the funding available to businesses and workers and widening access to grants to ensure we support as many people as possible. “In just four months we have announced more than £40 million in investment. We said we would back workers and businesses affected by the transition at Port Talbot and we are doing exactly that. “While this remains a very difficult time for Tata workers, their families and the community, we are determined to support workers and businesses in our Welsh steel industry, whatever happens.”