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Australian researchers have created building blocks out of DNA to construct a series of nano-scale objects and shapes, from a rod and a square to an infinitesimally small dinosaur. The approach turns DNA into a modular material for building nanostructures – thousands of times narrower than a human hair. Developed by researchers from the University of Sydney Nano Institute and published in the journal Science Robotics , it suggests exciting possibilities for future use of nanobot technology. As a proof-of-concept, the authors made more than 50 tiny shapes to test their precision and express their creativity. These included a dragon, a dinosaur, and a tiny map of Australia measuring only 150 nanometres wide. (A nanometre is one millionth of a millimetre.) University of Sydney scientist Dr Shelley Wickham, co-author of the paper and research team leader, said the dinosaur was her favourite because it had both compact and flexible parts and was “not something that could assemble by accident”. The director of RMIT’s micro nano research facility, Prof Arnan Mitchell, who was not involved with the paper, noted that the approach relied on using DNA as a mechanical object rather than as a chemical. This was interesting, he said, because structures made from DNA were potentially small enough to be used in drug delivery. DNA could be wrapped around a drug to protect it for delivery to a particular part of the body, he said. “Deliver it to where it needs to go, and then use light or heat or something else to make it unfurl and release the drug.” With increased complexity and greater control, Wickham said the researchers’ approach could be used to make components for robotic boxes capable of delivering targeted drugs, or in the development of smart materials that could respond to the environment. “This work enables us to imagine a world where nanobots can get to work on a huge range of tasks, from treating the human body to building futuristic electronic devices.” Sign up for Guardian Australia’s breaking news email Wickham outlined the process. The first step involved making the 3D building blocks, called “voxels”, she said. DNA, extracted from a type of virus called a bacteriophage, was “folded” into a cylindrical shape using an approach called DNA origami and held together with synthetic DNA (made by chemists). Voxels were formed by self-assembly, Wickham explained, relying on carefully sequenced DNA binding together at pre-determined locations, a bit like velcro or specialised glue. “We throw in 300 of these staples that all have a unique DNA sequence – like a unique glue – and they find different parts of the scaffold and stitch it together,” she said. Additional DNA strands incorporated on to the exterior of the voxels, acted as programmable binding sites. These could be used to join voxels together to construct more complex shapes and modular objects, which could be viewed under an electron microscope. “The results are a bit like using Meccano, the children’s engineering toy,” Wickham said. “As experimentalists, we spent a lot of time designing these on computers. And then we take the DNA and mix it together and it assembles itself.”

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Janette Manrara has sent her own message to Tasha Ghouri as she praised her husband's 'vulnerability' following their latest Strictly Come Dancing performance. Viewers of the hit dance show saw former Love Island star Tasha and her professional dance partner Aljaz Skorjanec bag the first perfect score of the 2024 series during the latest live show on Saturday night (November 23). In week ten of the BBC One dance contest, the pair performed an elegant American Smooth, which they dedicated to Aljaz's one-year-old daughter, Lyra. Tasha, who is the show’s second deaf contestant, performed a series of high lifts and dips during their dance to Someone You Loved by Lewis Capaldi to secure the top score of 40. READ MORE: Stacey Solomon addresses 'estranged' Joe Swash relationship after heading out solo with kids Head judge Shirley Ballas praised it as the "Rolls-Royce" of the American Smooth while Craig Revel Horwood described it as "fab-u-lous". Motsi Mabuse hailed it as "perfection" and said Tasha had brought the poignant song to life. Anton Du Beke, who got emotional during the performance, added that this is why dancers perform because of "how it makes us feel". But as the last performer of the night, Tasha had to do a quick change out of her flowing silver gown with a sparkly bodice into a blue sparkly dress with tulle detailing for a second number, the long-awaited return of the Dance-A-Thon after six year. It saw the seven remaining couples perform the samba simultaneously while the judges looked on and eliminated the pairings one by one before they were left with two. Tasha picked up an additional six points as she was voted runner-up behind JLS star JB Gill, who was named the winner of the dance, landing seven points. It was then during Sunday night's (November 24) results show that Tasha and Aljaz's fututre was confirmed as they made it through to week 11 of the dance programme and will perform during the Musicals Week special. Following the news, Tasha took to social media to reflect on her and Aljaz's continued Strictly journey. Tasha and Aljaz during their latest performance in the Strictly ballroom (Image: PA) Alongside pictures of her and Aljaz in action on the dance floor over the weekend, she said: "QUARTER FINALS HERE WE COME!! Thank you so so much for your votes and support, seeing how much you all loved the dance has just warmed my heart. Now I have gathered myself this is what I want to say.. "@aljazskorjanec your vulnerability this week has been so admirable. growing a friendship with you has been so special and to do this for Lyra this week, I felt so honoured! It’s so special that youve come back as a father & your passion for this show is what strictly is about, you are what strictly is. You always have a positive, joyous attitude! Especially this week you beamed everyday and I felt that! You have such a beautiful gorgeous wife @jmanrara & family, you all made me feel so welcome, thank you. "A celebration of family, love, friendships. This dance is truly the one I will keep bottled up ! The beauty of this show is the dancing and the joy it brings. NOW WE ARGENTINE TANGOOOOOO!!!! This is the one dance style and week I’ve been buzzing to do and it’s to SIX THE MUSICAL! @gemflossi @lisadaveyhair @vickygilldesign thank you team for this beautiful look!! The whole set, band, production team who work so hard to keep the magic going, thank you." Responding to the post, It Takes Two host Janette, who is married to Aljaz with whom she shares daughter Lyra, simply said: "You are beautiful in every way." Meanwhile, Strictly co-star JB Gill commented: "Stunner," while his professional dance partner replied: "Just stunning."

Van Nistelrooy returned to Old Trafford as Erik ten Hag’s assistant in the summer and had a four-game interim spell in charge following his compatriot’s sacking in October. He left the club in the wake of Ruben Amorim’s appointment but was only out of work for two weeks after being appointed Leicester’s new manager on a deal until 2027. The 48-year-old had a glittering playing career with United and was disappointed his return had to end so soon. “The moment I took over the interim job what I said was I’m here to help United and to stay to help United, and I meant it,” he said. “So I was disappointed, yeah, very much so, and it hurt I had to leave. “The only job I would take as an assistant was at United because of the bond that I have with the people in the club and the fans. “But in the end I got my head around it because I also understand the new manager. I’m in football long enough, and I’ve managed myself, that you can think of a situation, me being there, I understand. “I spoke to Ruben about it, fair enough to him, the conversation was grateful, man to man, person to person, manager to manager, and that helped a lot to move on and straightaway get into talks with new possibilities which of course lifted my spirits.” The Dutchman takes on a difficult job at the King Power Stadium as he is tasked with keeping Leicester in the Premier League. He inherits an influential dressing room, which has seen a number of managers come and go over the last few years. Ruud's here for his first press conference as our Manager 😃 — Leicester City (@LCFC) Van Nistelrooy revealed he has done his due diligence and also let the players know as well. “It’s the only way you can work. It’s mutual respect. I also mentioned to the players yesterday that I looked at the squad and started to make phone calls about players, because in football everyone knows everyone,” he said. “With two or three phone calls you hear stories about 20 players and for me it was important that you hear there are good characters there. That’s important, that there are good people there. “I look at the players how they play. I obviously don’t know them but I got general information and the individuals that they are a good bunch of people. That was important for me to get in.”

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Javon Small scored 31 points to rally West Virginia to an 86-78 overtime upset of No. 3 Gonzaga in the opening round of the Battle 4 Atlantis tournament, Wednesday in Nassau, Bahamas. The Mountaineers (4-1) trailed by 10 points early in the second half and by five in the final minute. But over the final 19 seconds of regulation, Tucker DeVries scored five straight points to send the game to overtime. In the extra session, Small scored five points and West Virginia held Gonzaga to a single field goal, which came after the outcome was decided with 19 seconds left. Amani Hansberry added a career-high 19 points and eight rebounds for West Virginia, which advances to the semifinals Thursday against another surprise first-round winner, Louisville, which stunned No. 15 Indiana. Braden Huff scored 19 points and Khalif Battle added 16 points for Gonzaga (5-1) which settles for a consolation-round game Thursday against Indiana. Nolan Hickman tallied 13 points. Ryan Nembhard delivered seven points and 12 assists for the Bulldogs. Huff put Gonzaga in position to win when he made three hook shots in the final 2:34 of regulation as the Bulldogs turned a one-point deficit into a 69-66 lead. Two free throws by Nembhard expanded the lead to 71-66 with 25 seconds left. But DeVries followed with a 3-pointer from the top of the key and then made a mid-court steal and drew a foul with 5.9 seconds left. His two free throws sent it to overtime. The Mountaineers never trailed in overtime. Sencire Harris wrapped it up with a steal and a breakaway slam that put West Virginia up 84-76 with 26 seconds left. Battle, a transfer from Arkansas, scored eight points in a span of 90 seconds late in the first half as the Bulldogs took control on their way to a 39-31 lead at the break. Gonzaga earned its biggest lead early in the second half when Graham Ike scored inside with an assist from Nembhard to make it 43-33. But West Virginia responded with a 17-2 run, fueled by Small as he hit two 3-pointers and two layups. Hansberry drained a trey and DeVries grinded for a putback layup to give the Mountaineers a 50-45 lead with 12:26 left. DeVries finished the game with 16 points and four blocks. --Field Level MediauLab® Announces Strategic Collaboration with Voxel and LuxCreo to Revolutionize Direct Print Aligner Technology

AMGEN TO PRESENT AT CITI'S 2024 GLOBAL HEALTHCARE CONFERENCE