super ace cheat Furthermore, the changing geopolitical landscape and evolving security threats have added complexity to the US-Russia relationship. Emerging challenges such as cyber warfare, disinformation campaigns, and proxy conflicts require innovative approaches to conflict resolution. Without a well-adapted conflict de-escalation mechanism, the ability to manage and mitigate these new threats is severely limited. - **Usage:** "I pulled an all-nighter last night to finish my research paper. I'm running on caffeine and sheer willpower today."O’Shea stands by decision to keep playing Collaros after QB was hurt in Grey Cup WINNIPEG — Mike O’Shea stood in front of reporters Friday and kept his cool while answering questions about the Winnipeg Blue Bombers’ 41-24 Grey Cup loss to the Toronto Argonauts last weekend. Judy Owen, The Canadian Press Nov 22, 2024 2:23 PM Nov 22, 2024 2:35 PM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Winnipeg Blue Bombers head coach Mike O'Shea walks onto the field for media availability ahead of the 111th CFL Grey Cup, in Vancouver, B.C., Friday, Nov. 15, 2024. THE CANADIAN PRESS/Darryl Dyck WINNIPEG — Mike O’Shea stood in front of reporters Friday and kept his cool while answering questions about the Winnipeg Blue Bombers’ 41-24 Grey Cup loss to the Toronto Argonauts last weekend. The head coach was asked if he made a mistake keeping injured quarterback Zach Collaros in the game, why star running back Brady Oliveira didn’t get the ball more and whether a flawed game plan led to Winnipeg’s third consecutive championship loss. “As an entire team, we didn’t have our best game,” O’Shea said in his end-of-the-season press conference. “We didn’t lack effort. We didn’t lack desire. “We didn’t have our best game as an entire team. Three phases. Coaches — everybody. Me especially.” O’Shea admitted he missed calling a timeout in the fourth quarter when there were only 11 Blue Bombers on the field instead of 12. “I don't get the count over the headset as quickly as I probably need to, we can't count. As I'm seeing a guy come off, that's the right time for that timeout that I should have used,” O’Shea said. He also said he should have used a challenge flag earlier on a play he didn’t identify, and checked on his players more during the game. But hindsight wouldn’t change his decision to put Collaros back in the game after the index finger on his throwing hand was cut deep when it hit a defender’s helmet. “He absolutely deserves every opportunity to lead this team,” O’Shea said. “From what I saw and from chatting with him very briefly, I felt really comfortable with that. I didn't think it was going to be easy, but I thought it's Zach, so...” The injury to Collaros’s finger happened late in the third quarter when the Blue Bombers were trailing the Argonauts 17-10. The veteran left the game and returned with a bandaged finger that needed five stitches and a numbing agent. He wore a glove on the hand and told reporters earlier this week it was difficult to grip the ball. Collaros said he warned receivers in the huddle his throws might not have the usual zip and they should be prepared to come back for the ball. “(I) saw him delivering the ball on the sidelines. Then you see him deliver a couple balls out there and some of them are pretty damn good, right?” O’Shea said. “The awareness of Zach to say to the receivers, ‘hey, work a little harder for me,’ I think it’s natural and what should be said. I think they already know that.” When Collaros re-entered the game, he threw interceptions in back-to-back series. “On one of them he got rid of the ball and I thought it was a good ball and the defensive player made a good play,” O’Shea said of the picks. “One slipped right out of his hand or I don't know if it got tipped or not. You've got to give him that opportunity.” Oliveira was questioning his lack of opportunities in the game when he spoke to reporters earlier in the week. The CFL’s newly minted most outstanding player and top Canadian only had 11 carries for 84 yards and one late touchdown. About 17 or 18 run plays were called, O’Shea said. “One starts off with a procedure penalty in the first and then six of those get pulled because there's X number of guys in the box or the read says this is not a run play anymore, this is now a pass play,” he said. “You call that many runs and then a pile of them get pulled because of the structure of the defence. That's OK with me at that point.” O’Shea said Bombers offensive co-ordinator Buck Pierce has been granted permission to talk to CFL teams with head-coaching job openings. The B.C. Lions are reportedly interested in Pierce. The Edmonton Elks also have a vacant head coach spot. If Pierce doesn’t become a head coach, O’Shea said he wants him to stay in Winnipeg. He believes Pierce had the offence “extremely well-prepared” for the Grey Cup. “I’m never going to question the play-calling, and I think what’s going on here is we’re questioning,” O’Shea said. “We’re trying to find blame and fault when that’s nowhere in our DNA of how we built this eight, nine, 10 years ago. We’re starting to try and find all these answers and question all these people that were 0-4 and 2-6 and then 10-1, and we just didn’t play our best game.” The Bombers finished 11-7 and claimed the West Division title that earned them a fifth consecutive trip to the Grey Cup. They won the championship in 2019 and ’21, but lost 28-24 to the Montreal Alouettes last year and 24-23 to Toronto in 2023. “We're the same group that got there, that went on a phenomenal run after a bad start, and a bad start for a lot of reasons that we overcame,” O’Shea said. “I just, I don't question any of it. I look for answers, too. I watch the film over and over and over again. And look to already make notes on how we're going to be better, how we're going to get back there again.” This report by The Canadian Press was first published Nov. 22, 2024. Judy Owen, The Canadian Press See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message More National Sports Grant-Mentis scores twice as Victorie beat Charge in PWHL pre-season Nov 22, 2024 2:25 PM Maple Leafs place Knies on injured reserve and add Alex Nylander on a one-year deal Nov 22, 2024 2:21 PM Hoops star Nurse joins Athletes Unlimited aiming to rebound from ‘rocky’ two years Nov 22, 2024 1:37 PM Featured FlyerPlans Required to Cover Treatment for SOD1-ALS ARLINGTON, Va. , Dec. 11, 2024 /PRNewswire/ -- The Centers for Medicare & Medicaid Services (CMS) has announced a first-of-its-kind directive requiring Medicare Advantage plans to approve coverage for Qalsody, a treatment for people living with genetic SOD1-ALS. This decision reflects the ALS Association's commitment to ensuring that people living with ALS have access to promising ALS treatments without delay. "This is a victory for the entire ALS community," said Calaneet Balas, president and CEO of the ALS Association. "It's critical that FDA-approved treatments are made accessible rather than being labeled as 'experimental.' We are grateful to everyone in our community who helped make this day happen." Balas added: "We hope this sends a message to the entire rare disease community and pharmaceutical industry that new treatments can be developed and made accessible to those who will benefit from them. We need to ensure more ALS treatments are developed and approved that will help everyone living with ALS." The ALS Association played a key role in the historic CMS directive by participating and advocating for the research, approval, and accessibility of Qalsody for people living with ALS. In 2004, the ALS Association was the first to fund research into ALS-specific antisense oligonucleotide (ASO) technology, investing over $1.3 million in groundbreaking studies that laid the foundation for the development of Qalsody. This early commitment supported preclinical studies, safety trials, and the first-in-human phase 1 trial, which established SOD1 as a viable therapeutic target. In 2023, Qalsody became the first gene-based therapy approved for ALS , thanks in part to the ALS Association's efforts, including a united push from the ALS community for FDA accelerated approval. This new CMS directive provides precedent for state regulators to issue similar actions for other private insurers. According to the Valor study published in 2022 , Qalsody, which was developed specifically to target the RNA produced by mutated SOD1 genes, has demonstrated significant promise in clinical trials and real-world studies. In the phase 3 VALOR trial, Qalsody reduced levels of mutated SOD1 proteins in cerebral spinal fluid by 35% within eight weeks and decreased bloodstream levels of neurofilament light chain (NfL)—a key biomarker of neurodegeneration—by 50% within 12-16 weeks. These biological changes translated into measurable clinical benefits, including slower disease progression, improved respiratory function, and enhanced quality of life after 52 weeks of treatment. Real-world data has since validated these findings, with some patients stabilizing or even experiencing improvements in motor function and quality of life. When insurance companies began denying access to Qalsody, labeling it as "experimental," the ALS Association took decisive action, working directly with CMS to launch an investigation into these unjust denials. By presenting evidence of widespread insurance rejections and demonstrating the critical need for immediate intervention. In addition to working with CMS, the ALS Association actively engaged policymakers, held strategic meetings with state and federal legislators, and served as a staunch advocate for patients, ensuring their voices were heard and their rights to life-changing treatment were upheld. The ALS Association urges anyone previously denied Qalsody by their Medicare Advantage plan to contact their ALS specialist immediately to begin the process of securing access to this critical treatment. For more information on the CMS directive visit als.org About the ALS Association The ALS Association is the largest ALS organization in the world. The ALS Association funds global research collaborations, assists people with ALS and their families through its nationwide network of care and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association is working to make ALS a livable disease while urgently searching for new treatments and a cure. For more information about the ALS Association, visit our website at www.als.org . About ALS Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Over the course of the disease, people lose the ability to move, to speak, and eventually, to breathe. The disease is always fatal, usually within five years of diagnosis. Few treatment options exist, resulting in a high unmet need for new therapies to address functional deficits and disease progression. View original content to download multimedia: https://www.prnewswire.com/news-releases/groundbreaking-directive-ensures-als-patients-on-medicare-advantage-gain-access-to-qalsody-302329525.html SOURCE The ALS Association

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