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NoneScientists identify brain cell type as master controller of urination December 3, 2024 eLife Researchers have identified a subset of brain cells in mice that act as the master regulators of urination. Facebook Twitter Pinterest LinkedIN Email Researchers have identified a subset of brain cells in mice that act as the master regulators of urination. The research, published today as a Reviewed Preprint in eLife , is described by editors as an important study with convincing data showing that estrogen receptor 1-expressing neurons (ESR1+) in the Barrington's nucleus of the mouse brain coordinate both bladder contraction and relaxation of the external urethral sphincter. Urination requires the coordinated function of two units of the lower urinary tract. The detrusor muscle of the bladder wall relaxes to allow the bladder to fill and empty, while the external sphincter opens when it's appropriate to allow urine to flow out, but otherwise keeps tightly shut. "Impairment of coordination between the bladder muscle and the sphincter leads to various urinary tract dysfunctions and can significantly degrade a person's quality of life," says first author Xing Li, Advanced Institute for Brain and Intelligence, School of Physical Science and Technology, Guangxi University, Nanning, China. "But although we know the individual nerve signalling pathways that control each of these urinary tract components, we don't know which brain areas ensure they cooperate at the right time." To explore this, the authors used state-of-the-art live cell imaging to study the activity of brain cells in anaesthetised and awake mice during urination. They focused on a brain region called the pontine micturition centre (PMC), otherwise known as the Barrington's nucleus, and compared the activity of different PMC nerve cell subtypes. In their first experiments, they measured the activity of the cells as the bladder empties by measuring changes in levels of calcium. This revealed that the electrical firing rate of a subset of PMC cells expressing estrogen receptors (PMC ESR1+ cells) was tightly linked to bladder emptying. When they combined this with monitoring bladder physiology, they found that it was not only the timing of PMC ESR1+ cell activity that correlated with bladder emptying, but the strength of cell electrical activity, too. Next, they tested what happened to urination if they blocked or triggered the PMC ESR1+ cells. They found that when PMC ESR1+ cell activity was blocked, the amount of urine the mice passed was significantly reduced and ongoing urination was suspended from the moment the cells were inactive. To understand the mechanism behind this, they measured the activity of the bladder muscle and sphincter. They discovered that both increase of bladder pressure and sphincter muscle bursting activity associated with bladder emptying both stopped when PMC ESR1+ cell activity was blocked during an ongoing voiding even. Similarly, when PMC ESR1+ cells were artificially activated using light, bladder emptying occurred 100% of the time. This suggests that PMC ESR1+ cells work as a reliable master switch that either initiates or suspends bladder emptying. To test whether PMC ESR1+ cells can influence bladder emptying independently of controlling the sphincter, they disconnected either the nerve carrying messages from the brain to the sphincter, or the nerve carrying messages from the brain to the bladder. They found that PMC ESR1+ cell control of the bladder was fully operational even when communication to the sphincter was blocked, and vice versa. This showed the cells could control the bladder and sphincter independently of one another, but the question remained: could they coordinate the action of the bladder muscle and sphincter together? That is, operate them in a controlled, perfectly timed manner, to trigger bladder emptying when appropriate? To explore this, they simultaneously recorded bladder pressure and electromyography measurements of sphincter activity. The timing of bladder pressure changes immediately before sphincter bursting activity was consistent for both spontaneous bladder emptying and emptying caused by activating the PMC ESR1+ cells, showing that these cells can coordinate the two steps in a precisely temporal sequence and controlled way. "Our study shows that a subset of cells in the Barrington's nucleus of the brain can initiate and suspend bladder emptying with 100% accuracy when needed, for example, to release only a small volume for landmarking by animals, or for a human to urinate into a small sample tube for a health check," concludes senior author Xiaowei Chen, Third Military Medical University, and Chongqing Institute for Brain and Intelligence, China. "While other cells will no doubt be involved in perfect urination control, our pinpointing of PMC ESR1+ cells' crucial role in bladder-sphincter coordination will aid the development of targeted therapies for treating urination dysfunction caused by brain or spinal cord injury or peripheral nerve damage." Story Source: Materials provided by eLife . Note: Content may be edited for style and length. Journal Reference : Cite This Page :

Biden not answering questions about pardoning his son Hunter'Erik ten Hag was the problem!' - Man Utd 'made a mistake' by letting 'coaching genius' Ruud van Nistelrooy leave after convincing win in first game with Leicester - Goal.com

The Executive Vice Chairman/Chief Executive Officer of the National Agency for Science and Engineering Infrastructure (NASENI), Mr Khalili Halilu, has said the agency will leverage the power of digital media in communicating Nigeria’s industrialisation drive through NASENI and promote the Renewed Hope Agenda of the present administration. While declaring open a 3-day Training Workshop for the Agency’s Staff Writers and Online Media Partners with the theme, “Enhancing Effective Delivery of Communication Objectives in a Changing Digital Environment”, on Wednesday at NASENI Headquarters, Abuja, the EVC stated that the Agency was committed to driving Nigeria’s industrialization through innovation and technology. He added that effective communication was therefore vital to achieving this pursuit and that the outcome of the training will enable the team to amplify the Agency’s message further, engage its audience, and showcase achievements. According to him, the training was amongst the series of ongoing training courses aimed at enhancing capacity development for staff and repositioning the Agency for greater service delivery. “I believe that the knowledge gained during these three days will in turn increase your understanding and capacity to deliver on the job of propagating positive messages about our Agency.” The EVC of NASENI said: “As we navigate the ever-evolving digital media landscape, it is crucial that we stay focused on the content of our narratives while keeping ourselves abreast of the latest trends, ethics, tools, and best practices. This training is designed to equip you with the knowledge and skills necessary to excel in these roles.” In her goodwill message, the Coordinating Director, Planning and Business Development Directorate, NASENI, Dr Mrs Nonyem Onyechi, urged the participants to make the best of the knowledge and skills gained from the workshop and to utilize them to promote the Agency’s products, and research and development initiatives. Earlier In his welcome address, the Director of Information, New Media and Protocol, Mr. Segun Ayeoyenikan noted that with the visionary leadership of Mr. Halilu, NASENI is now the leading technology Agency of the Federal Government, driving the Renewed Hope agenda of President Bola Ahmed Tinubu government, whose focus primarily is the socio-economic transformation of the country. Highlighting the importance of the workshop, he said it will ensure a paradigm shift for more strategic and deliberate narratives to tell compelling technology-innovation-driven new Nigeria economy through NASENI with Halilu in the driver’s seat. Also speaking, the Lead Consultant and Chief Executive Officer, of Fort Realm Global Limited, Mr. John Bakare, the organizer of the workshop, said it aims to build the capacity of NASENI’s Information and Communication team and its media partners, equipping them with strategic skills necessary to design and implement robust communication strategies, including social media plans, to enhance the Agency’s public outreach.

NEW YORK (AP) — President-elect Donald Trump’s lawyers formally asked a judge Monday to throw out his hush money criminal conviction , arguing that continuing the case would present unconstitutional “disruptions to the institution of the Presidency.“ In a filing made public Tuesday, Trump’s lawyers told Manhattan Judge Juan M. Merchan that anything short of immediate dismissal would undermine the transition of power, as well as the “overwhelming national mandate" granted to Trump by voters last month. They also cited President Joe Biden’s recent pardon of his son, Hunter Biden, who had been convicted of tax and gun charges . “President Biden asserted that his son was ‘selectively, and unfairly, prosecuted,’ and ‘treated differently,’" Trump’s legal team wrote. Manhattan District Attorney Alvin Bragg, they claimed, had engaged in the type of political theater "that President Biden condemned.” Prosecutors will have until Dec. 9 to respond. They have said they will fight any efforts to dismiss the case but have indicated a willingness to delay the sentencing until after Trump’s second term ends in 2029. In their filing Monday, Trump's attorneys dismissed the idea of holding off sentencing until Trump is out of office as a “ridiculous suggestion.” Following Trump’s election victory last month, Merchan halted proceedings and indefinitely postponed his sentencing, previously scheduled for late November, to allow the defense and prosecution to weigh in on the future of the case. He also delayed a decision on Trump’s prior bid to dismiss the case on immunity grounds. Trump has been fighting for months to reverse his conviction on 34 counts of falsifying business records to conceal a $130,000 payment to porn actor Stormy Daniels to suppress her claim that they had sex a decade earlier. He says they did not and denies any wrongdoing. The defense filing was signed by Trump lawyers Todd Blanche and Emil Bove, who represented Trump during the trial and have since been selected by the president-elect to fill senior roles at the Justice Department. Taking a swipe at Bragg and New York City, as Trump often did throughout the trial, the filing argues that dismissal would also benefit the public by giving him and “the numerous prosecutors assigned to this case a renewed opportunity to put an end to deteriorating conditions in the City and to protect its residents from violent crime.” Clearing Trump, the lawyers added, would also allow him to “to devote all of his energy to protecting the Nation.” Merchan hasn’t yet set a timetable for a decision. He could decide to uphold the verdict and proceed to sentencing, delay the case until Trump leaves office, wait until a federal appeals court rules on Trump’s parallel effort to get the case moved out of state court or choose some other option. An outright dismissal of the New York case would further lift a legal cloud that at one point carried the prospect of derailing Trump’s political future. Last week, special counsel Jack Smith told courts that he was withdrawing both federal cases against Trump — one charging him with hoarding classified documents at his Florida estate, the other with scheming to overturn the 2020 presidential election he lost — citing longstanding Justice Department policy that shields a president from indictment while in office. The hush money case was the only one of Trump’s four criminal indictments to go to trial, resulting in a historic verdict that made him the first former president to be convicted of a crime. Prosecutors had cast the payout as part of a Trump-driven effort to keep voters from hearing salacious stories about him. Trump’s then-lawyer Michael Cohen paid Daniels. Trump later reimbursed him, and Trump’s company logged the reimbursements as legal expenses — concealing what they really were, prosecutors alleged. Trump has said the payments to Cohen were properly categorized as legal expenses for legal work. A month after the verdict, the Supreme Court ruled that ex-presidents can’t be prosecuted for official acts — things they did in the course of running the country — and that prosecutors can’t cite those actions to bolster a case centered on purely personal, unofficial conduct. Trump’s lawyers cited the ruling to argue that the hush money jury got some improper evidence, such as Trump’s presidential financial disclosure form, testimony from some White House aides and social media posts made during his first term. Prosecutors disagreed and said the evidence in question was only “a sliver” of their case. If the verdict stands and the case proceeds to sentencing, Trump’s punishments would range from a fine to probation to up to four years in prison — but it’s unlikely he’d spend any time behind bars for a first-time conviction involving charges in the lowest tier of felonies. Because it is a state case, Trump would not be able to pardon himself once he returns to office.Hunter Biden gun case dismissed after President Joe Biden's sweeping pardon

49ers turning to Kyle Allen with Brock Purdy ruled out for critical Packers matchupNone

When the snow is falling and hot chocolate is piping, few activities are more refreshing and relaxing than plopping down on the couch and turning on the television. Some will watch live Christmas events from Rockefeller Center, while others will tune into a bowl game. But if you’re of a certain age, you clearly remember the excitement when Nickelodeon began to roll out its litany of timeless Christmas specials. From Kenan & Kel in the 1990s to Danny Phantom in the late 2000s, Nickelodeon has entered the pantheon of networks that have consistently rolled out classic holiday specials. While Nickelodeon’s legacy is cemented, the ranking of its best holiday season episodes is and will always be hotly contested. Not to start a debate at the holiday dinner table, but here are the 10 best classic Nickelodeon holiday specials. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Success! An email has been sent to with a link to confirm list signup. Error! There was an error processing your request. Get the latest need-to-know information delivered to your inbox as it happens. Our flagship newsletter. Get our front page stories each morning as well as the latest updates each afternoon during the week + more in-depth weekend editions on Saturdays & Sundays.Horoscope Today, December 4, 2024: Explore Astrological Insights For Your Zodiac Sign

The Western and Central Pacific Fisheries Commission (WCPFC) is aiming to improve standards for crew aboard fishing vessels operating in the region. At its just-finished conference in Suva, the Commission agreed to implement measures aimed at ensuring fair pay, safe and decent working conditions, and protections against forced labour and other abuses. Forum Fisheries Agency (FFA) deputy director general Dr Pio Manoa said the new labour standards are crucial to ensure the safety and dignity of crew. Pio said the FFA members have been key drivers of this initiative, reflecting the agency's collective commitment to social responsibility in fisheries management. Meanwhile, non-government organisation Pew Charitable Trust said the WCPFC is making a critical effort to modernise oversight of the world's largest tuna fishery. The Commission has adopted interim electronic monitoring standards - after ten years of effort - which will ultimately help improve oversight of the region's valuable fisheries. The move means the work of human observers will be augmented by onboard cameras and other technology. An officer for the Pew Charitable Trusts' international fisheries project Dave Gershman said electronic monitoring will increase data collection and help ensure that fishers are following the Commission's rules. However, he said the Commission has again failed to agree to on ways to improve the transparency of transshipment of fish catches. Pew said the Commission's rules on transshipment remain out of alignment with UN recommendations and lag behind standards adopted by the other four tuna regional fisheries management organisations.During his first-ever visit to Pakistan, General Tan Sri Dato’ Sri Mohd Asghar Khan bin Goriman Khan, Chief of the Royal Malaysian Air Force called on Air Chief Marshal Zaheer Ahmed Baber Sidhu, Chief of the Air Staff, Pakistan Air Force on Friday at Air Headquarters. The meeting focused on matters of mutual interest, military cooperation, joint training and collaboration in the industrial domain, said a news release issued by Inter Services Public Relations (ISPR). On his arrival, a smartly turned-out contingent of Pakistan Air Force presented Guard of Honour to General Tan Sri Dato’ Sri Mohd Asghar Khan bin Goriman Khan. During the meeting, Chief of the Air Staff highlighted the robust bilateral defence ties that exist between Pakistan and Malaysia. He conveyed his warm wishes to Chief of the Royal Malaysian Air Force on his maiden visit to Pakistan and highlighted the importance of collaboration in training, joint exercises and technology sharing. The Air Chief also reaffirmed his commitment to enhancing military partnership between the two Air Forces through joint training initiatives, particularly within the realm of air power. These initiatives will encompass provisioning of both basic and tactical level training for personnel of the Malaysian Air Force. The Chief of the Royal Malaysian Air Force lauded Pakistan Air Force’s achievements through indigenization and technological advancements. The visiting dignitary expressed his keen desire to further consolidate the existing bilateral ties through enhanced collaboration in training, maintenance and operational excellence. General Tan Sri Dato’ Sri Mohd Asghar Khan bin Goriman Khan expressed his deep admiration for the state of the art technological ecosystem witnessed by him during his visit to National Aerospace Science & Technology Park Silicon. He also appreciated the innovative projects, cutting-edge technologies and indigenously developed systems displayed at PAF NASTP pavilion during the ongoing International Defence Exhibition IDEAS-2024. Later, the dignitary visited various installations and technological infrastructure established at Air Headquarters, Islamabad including National ISR & Integrated Air Operations Centre and PAF Cyber Command, where he was briefed about the operational capabilities of Pakistan Air Force. The meeting between Chief of the Air Staff, Pakistan Air Force and Chief of the Royal Malaysian Air Force signifies a resolute commitment to reinforce military partnership, fostering collaboration and promoting robust relations between the two countries.

A short Christmas benediction from the past that has aged quite well

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Rising Demand from the Food and Beverage Industry: A Key Driver Transforming the Oxygen Scavenger Market 2024When the snow is falling and hot chocolate is piping, few activities are more refreshing and relaxing than plopping down on the couch and turning on the television. Some will watch live Christmas events from Rockefeller Center, while others will tune into a bowl game. But if you’re of a certain age, you clearly remember the excitement when Nickelodeon began to roll out its litany of timeless Christmas specials. From Kenan & Kel in the 1990s to Danny Phantom in the late 2000s, Nickelodeon has entered the pantheon of networks that have consistently rolled out classic holiday specials. While Nickelodeon’s legacy is cemented, the ranking of its best holiday season episodes is and will always be hotly contested. Not to start a debate at the holiday dinner table, but here are the 10 best classic Nickelodeon holiday specials. Show: Keenan & Kel Air Date: December 14, 1996 Kel ( Kel Mitchell ) loves orange soda and Kenan ( Kenan Thompson ) loves Christmas. He spends the entire year saving money to buy a new bike and takes an extra job as Santa at the mall to help get the last few dollars he needs. However, his plans are derailed when he comes across a brother and sister who dream of a great Christmas filled with presents that their mother can’t afford. In a selfless mood, Kenan uses the money he makes as Santa to surprise the kids and their mom with presents. Kenan’s upset that he didn’t get the bike he wanted, but he knows he did the right thing and Santa rewards him with a bike of his own. As with many Nickelodeon holiday specials, Kenan’s act of giving underscores the importance of family, friends, community, and giving throughout the holiday season. Show: Invader Zim Air Date: December 10, 2002 Name two more idiotically entertaining rivals than Zim ( Richard Steven Horvitz ) and Dib (Andy Berman). I’ll wait. While I wait, also figure out why Dib’s dad, Professor Membrane ( Rodger Bumpass ), named him Dib. Anyway, Zim and Dib’s rivalry takes center stage when Zim learns about the lure of Santa, kidnaps a man dressed up in a Santa suit and drains his brain. Normal holiday festivities, right? Once Zim drains the man’s brain and learns more about the lure of Santa, he devises a plan to build a Santa suit and convince all of humankind that he’s worthy of following and giving their undying devotion too. For the most part, it works and Zim is close to bringing all of human kind to the Tallest in order to extend his rule. However, Dib intervenes and garners the support of his sister, Gaz (Melissa Fahn), and his father, Professor Membrane, and stops Zim before he’s able to fully takeover. Overall, it’s a pretty weird storyline for a kid’s show during the holiday season, but Invader Zim is at its best when it’s weird. Show: Rocko’s Modern Life Air Date: December 1, 1994 Rocko ( Carlos Alazraqui ) is a better person than most because his grace throughout this Christmas special is unmatched. For nearly the entire episode, Rocko works to put together beautiful holiday decorations and host a lovely holiday party. Instead, his friends treat him poorly, other characters bully him, and no one except a magic elf shows up to his party. The elf works his magic and creates a memorable snowfall around Rocko’s house and Rocko’s house only. When the blizzard leaves a perfect amount of snow and holiday cheer around his house, Rocko’s friends show up at his front door to apologize and make the most of the holiday party. Rocko, being the kind soul he is, lets them in and thanks them for coming. Show: iCarly Air Date: December 13, 2008 Timmy Turner ( Tara Strong ) isn’t the only character in the Nickelodeon multiverse to have their dreams come true during the holiday season. When Carly’s brother, Spencer ( Jerry Trainor ), builds an electromagnet Christmas tree that sets fire to holiday gifts, Carly ( Miranda Cosgrove ) wishes that her brother was a bit more normal. However, things aren’t as great as Carly hoped they’d be. Spencer becomes a “normal” lawyer dating Ms. Benson (Mary Scheer) while Freddie ( Nathan Kress ) no longer has a crush on Carly, and Sam ( Jennette McCurdy ) is in a juvenile detention center. Most shockingly, Carly, Spencer, and Freddie were never friends in this alternate universe and never launched a webcast. The weirdness of the episode pays off in the end because Carly realizes what we’ve always known: her life is pretty great as is. Show: As Told by Ginger Air Date: December 10, 2001 As Told by Ginger is one of the most underrated series in the Nickelodeon catalog for various reasons, including its humor and ability to reach both young and older audiences. Case in point, the show’s “Even Steven” holiday special is immaculate. In the tertiary plot, Ginger (Melissa Disney) discovers that her grandfather is Jewish and immediately pivots from celebrating Christmas to celebrating Hanukkah. Her shift from Christmas to Hanukkah happens so quickly that it causes a rift between her and Dodie (Aspen Miller) because Ginger refuses to go to Dodie’s Christmas party and hosts her own instead. Splitting the room down the middle, half of Ginger’s party is devoted to celebrating Hanukkah, and the other half is adorned with Christmas decorations. Meanwhile, Hoodsie ( Tress MacNeille) is writing letters to Santa, asking him to give him rhythm for Christmas. Yes, you read that correctly. He genuinely asked Santa for rhythm, the ability to dance on beat. When Ginger’s brother, Carl (Jeannie Elias), finds Hoodsie begging Santa for rhythm, he not only makes fun of him, but also declares that Santa isn’t real. As a result, Carl spends the remainder of the episode attempting to prove that Santa is real. Through this effort, he learns that Carl is not a fan of the holiday season because he routinely asked Santa to bring his father home for Christmas as a kid, and his dad rarely stopped by on the holidays. With this information, Hoodsie runs up to a man dressed as Santa on the street and asks him to bring Hoodsie’s Dad home for Christmas. Little does Hoodsie know, the man dressed up as Santa is Carl’s dad. In the end, Carl’s dad visits him for Christmas, and while they’re talking in the driveway, a fire starts inside as Ginger is hosting her holiday party. Carl’s dad runs in, puts out the fire, and saves the day, making Ginger realize that the most important part of the holidays is being surrounded by family and friends. And no, Carl does not get rhythm. Show: The Fairly OddParents Air Date: December 12, 2001 Clichés may be annoying, but they’ve stood the test of time for a reason. However, when an elder said, “Be careful what you wish for,” Timmy Turner clearly wasn’t listening. Instead, he had to learn the hard way when he told Wanda (Susanne Blakeslee) and Cosmo ( Daran Norris ) that he’d like it to be Christmas every day. In his head, there’d never be school, and he’d get presents every time he woke up. Conversely, Wanda and Cosmo are magically depleted, his parents can’t work, and the other holidays become envious of Santa Claus. As a result, Timmy must make a trip up to the North Pole all alone. Tough luck for a kid who can literally wish for whatever he wants every other day of the year already. Show: Drake & Josh Air Date: December 5, 2008 Give a little girl named Mary Alice the best Christmas ever, or go back to jail. That’s essentially the plot of “Merry Christmas, Drake and Josh.” Drake ( Drake Bell ) desperately wants to host a party on the rooftop of Josh’s workplace, Premier Theater. To the surprise of just about everyone, Josh’s boss agrees to let Drake host the party as long as he volunteers to dress up as Santa for kids in the mall. Drake agrees, but things go haywire when a woman tries to kiss him, and he runs away. While hiding, he runs into a little girl named Mary Alice ( Bailee Madison ) and promises to give her the best Christmas ever. Drake finishes his shift as Santa and gets to host the party after all, but it’s cut short when a few uninvited guests show up, and Josh ( Josh Peck ) calls the police. However, there’s a mixup when the police arrive and Josh gets arrested. Being the good stepbrother he is, Drake tries to break Josh out of jail. Unfortunately, Drake gets arrested, too. When Drake and Josh get to speak to a judge, they explain that they need to get out to fulfill Drake’s promises to Mary Alice. The judge releases them, but warns that they will be brought back if they do not give Mary Alice the best Christmas ever. No pressure, right? Show: Rugrats Air Date: December 6, 1992 It may not seem like it, but there is not much of a difference between The Boondocks ‘ Huey Freeman ( Regina King ) and the children of Rugrats . Huey chases Santa around the mall with a BB gun, screaming, “You gon’ pay what you owe.” Meanwhile, Tommy ( Elizabeth Daily ), Chuckie (Christine Cavanaugh), and the crew are setting dangerous traps for Santa , so they can question him about his character. “The Santa Experience” kicks off at the mall where Angelica (Cheryl Chase) bum rushes the line to see Santa and tells Mr. Claus how much she needs a dream dollhouse for Cynthia. While Mr. Claus pushed her away, mall staff gave her a box of free toys to apologize for Santa rightfully pushing her away. Even with the free presents, Angelica is ungrateful and doesn’t want them. Meanwhile, Tommy and Chuckie are debating whether or not Santa is a good person. You know, typical baby stuff, right? Tommy is convinced Santa is a great guy, while Chuckie is, of course, scared of Saint Nick and thinks he’s a bad guy. In the kitchen, the parents are having a relatable conversation about their challenges and struggles, trying to ensure each of their children has a good holiday season. Later, the kids and parents head north to celebrate Christmas in a cabin. There, Chuckie and Tommy set up a booby trap to catch Santa. Much to their disappointment, the trap only manages to catch Stu ( Jack Riley ). Ultimately, everything turns out for the best as Santa just rings the front doorbell and delivers the presents face-to-face. Angelica gets her doll house, Chuckie determines Santa is a good person after all, and the Rugrats get the perfect Christmas. Show: SpongeBob SquarePants Air Date: December 6, 2000 If you ask most fans of SpongeBob SquarePants about Squidward (Rodger Bumpass), most would say he’s closer to being the Grinch than Santa Claus. However, “Christmas Who?” proves otherwise. Spongebob ( Tom Kenny ) visits Sandy ( Carolyn Lawrence ) and finds the proud Texan setting up Christmas decorations around her house. Instead of helping her, Spongebob freaks out because he thinks the lights and decorations have started a fire. It would be nearly impossible to start a fire that far underwater, but I digress. Anyway, Sandy stops him and explains to Spongebob who Santa Claus is and what happens on Christmas. Excited and enchanted, Spongebob shares the story of Christmas and Santa Claus with nearly everyone in Bikini Bottom. As a result, everyone but Squidward sends letters to Santa and spends all night caroling. When Santa doesn’t show up, everyone calls Spongebob a fraud and mocks him, including Squidward. However, Spongebob turns Squidward’s heart from coal to gold when he gives him a handcrafted clarinet for Christmas so that he won’t go without a gift. In return, Squidward dresses up as Santa and surprises Spongebob, who is delighted, and wishes him a merry Christmas. Squidward didn’t account for all of the other citizens of Bikini Bottom spotting him and asking for gifts. Instead of ruining the charade, Squidward ends up giving away nearly everything in his home away as a gift. Thankfully, Squidward is rewarded when the real Santa Claus sends a letter thanking Squidward for helping keep the spirit of Christmas alive. Show: Hey Arnold! Air Date: December 11, 1996 “Arnold’s Christmas” is not only the best Nickelodeon late-year holiday special, but it’s arguably one of the best episodes of the entire series. The series revolves around Arnold (Toran Caudell) attempting to pull off a Christmas miracle for his neighbor, Mr. Hyunh (Baoan Coleman). Through this endeavor, much of Mr. Hyunh’s backstory is revealed, including the heartbreaking story of how he and his daughter, Mai (Hiep Thi Le), have been separated for more than 20 years. While Arnold and his best friend, Gerald (Jamil Walker Smith), fall short in their quest to find Mai and reconnect her with Mr. Hyunh, Helga (Francesca Marie Smith) unexpectedly saves the day and gets Mai in touch with her father. Helga never gets the credit for creating this touching reunion, but she will always be remembered for being the driving force behind one of the most touching moments in Nickelodeon history. More Headlines: Saint Nick-Mas: 10 Best Nickelodeon Holiday Specials, Ranked Who Had the Best Holiday Movies of 2024? Hallmark vs. Lifetime vs. Netflix (POLL) ‘Squid Game’ Season 3: Everything We Know So Far ‘Shrinking’ Boss Breaks Down Finale’s Scary Louis Moment & What’s Ahead for Season 3 Wendy Williams Is ‘Sober’ & Wants to Go Home From Care Facility Says Son

( MENAFN - GlobeNewsWire - Nasdaq) DUBAI, United Arab Emirates, Dec. 24, 2024 (GLOBE NEWSWIRE) -- BricklayerDAO is setting a new standard in the intersection of blockchain technology and real estate. Frustrated by the limited returns and lack of control in traditional Real estate investment, Nick and Denis founded a platform that merges the flexibility of blockchain Technology with the stability of real estate investment trusts (REITs). Their extensive experience in commercial real estate, spanning a collective 30 years and encompassing billions in transactions, has paved the way for an innovative model. This model not only reduces barriers to entry for institutional-grade real estate but also empowers investors by providing unprecedented levels of participation. At its core, BricklayerDAO operates on two tokens that drive its ecosystem: MRTR , a utility token central to governance, and BRCK , a value token directly tied to real-world assets (RWAs). Nick explains this model,“Our dual-token system is designed to ensure robust engagement and transparency while empowering holders to influence investment strategies directly. MRTR tokens give stakeholders a voice in governance through staking and voting, with innovative quadratic voting mechanisms that balance power between large and small holders. At the same time, $BRCK tokens derive their value from tokenised real-world assets, such as industrial warehouses leased by Fortune 50 companies on long-term agreements, offering the community a cash flow-backed and tangible investment opportunity.” The DAO's governance system is designed with meticulous attention to community-driven decision-making. From idea formulation to final implementation, members contribute at every stage, with proposals rigorously vetted through forums, temperature checks, and voting. Further, BricklayerDAO's operations are underpinned by a commitment to efficient capital reserves. Fiat accounts, maintained in local jurisdictions for operational requirements, are transparently monitored through blockchain oracles, bridging the gap between traditional and digital economies. Virtual assets, including Bitcoin and Ethereum, are managed through the Quarry , the platform's digital mining network, contributing to the steady growth of reserves while offering stability in volatile markets. This dual-exposure strategy enables BricklayerDAO to balance growth and liquidity effectively. Denis highlights,“What truly sets BricklayerDAO apart is the seamless integration of PropTech innovations with decentralised finance. By tokenising real estate assets and utilising Chainlink oracles, we bridge the gap between off-chain value and blockchain technology, creating a transparent and efficient system that redefines how real estate investments are managed.” By acquiring and managing both traditional and tokenised real estate, BricklayerDAO opens institutional-grade opportunities to a global audience without compromising on diligence or asset quality. Its acquisition strategy prioritises industrial assets with high-credit tenants, maximising rental yields while supporting long-term value appreciation for BRCK holders. Central to the DAO's mission is its tenant-friendly approach, designed to reduce costs and nurture flexibility for occupiers. Partnerships with key stakeholders create an equitable real estate ecosystem that aligns the interests of investors and tenants. Through the Bricktop A.I real estate assistant tool, BricklayerDAO simplifies opportunity identification and asset management, integrating data-driven insights to optimise site selection, leasing, and market positioning. The Masonry (MSRY) NFTs add a unique dimension to the ecosystem, offering members benefits ranging from early access to services and fee discounts to boosted governance influence. Available in four rarity tiers: Clay, Granite, Marble, and Special , these NFTs reward active community participation while promoting loyalty. BricklayerDAO's Kiln mechanism further incentivises engagement by linking NFT distribution to $BRCK token purchases, ensuring alignment between token value and user benefits. BricklayerDAO's entry into the market also marks a significant step in preparing the real estate industry for a new era of blended assets. By advancing Web3 technologies, the DAO provides real estate vendors with tools for efficient, transparent, and globally accessible transactions. Its efforts are shaping the gig economy's role in property management and investment, allowing real estate professionals and on-chain enthusiasts to engage in every facet of RWA transactions. Nick shares his enthusiasm,“Launching BricklayerDAO is a monumental step for us, and we're genuinely thrilled to bring this vision to life. We've built this platform with a strong foundation of trust, transparency, and innovation, ensuring that it serves the best interests of the market and its participants. We are dedicated to building the world's most verifiable RWA value offering ecosystem on-chain.” Denis adds,“This isn't just about creating a platform; it's about setting a new standard for real estate and blockchain integration. We're committed to delivering value and opportunity in good faith to our investors, the community, and the broader industry, paving the way for a more inclusive and equitable future.” BricklayerDAO invites investors and real estate professionals to join this transformative journey. As it continues to redefine property investment, the DAO offers not only a platform but a community, a space where collaboration and innovation pave the way to a more inclusive and efficient real estate ecosystem. Also, the MRTR presale is now live , and we'd love for you to participate! Don't miss out. Click here to buy your tokens today! You can stay up-to-date with BricklayerDAO by following them on social media platforms such as X , Discord , LinkedIn and Instagram ___________________________________ For media inquiries, please contact: Contact Person Name: Stuart Alldus Designation: Head of Investor Relations Email: ... About BricklayerDAO: BricklayerDAO is a groundbreaking platform that merges blockchain technology with real estate investment, offering a decentralised approach to property transactions. By tokenising real-world assets and empowering stakeholders through governance, BricklayerDAO creates a transparent, accessible, and community-driven ecosystem for the future of real estate and blockchain integration. ___________________________________ Disclaimer: This content is provided by BricklayerDAO. The statements, views and opinions expressed in this column are solely those of the content provider. The information provided in this press release is not a solicitation for investment, nor is it intended as investment advice, financial advice, or trading advice. It is strongly recommended you practice due diligence, including consultation with a professional financial advisor, before investing in or trading cryptocurrency and securities. Please conduct your own research and invest at your own risk. A photo accompanying this announcement is available at MENAFN24122024004107003653ID1109028855 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.New virtual golf facility planned for Rickmansworth course

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